TY - JOUR
T1 - The inflammatory milieu of eosinophilic esophagitis
T2 - A contemporary review with emphasis in putative immunohistochemistry and serologic markers
AU - Lepe, Marcos
AU - O'Connell, David
AU - Lombardo, Kara A.
AU - Herzlinger, Michael
AU - Mangray, Shamlal
AU - Resnick, Murray B.
AU - Matoso, Andres
N1 - Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Eosinophilic esophagitis is a chronic disease characterized by esophageal dysfunction, frequent clinical history of atopy, and eosinophilic inflammation of the esophagus. Within the esophageal mucosa, there is a wide variety of immune mediators, chemotactic factors, mediators of transcription, and markers of epithelial differentiation and integrity that are overexpressed or underexpressed in eosinophilic esophagitis, offering many candidates for biomarkers with diagnostic or prognostic potential. In this review, we summarize the results from studies performed so far to evaluate the detection of these markers by immunohistochemistry on esophageal biopsies. In addition, we briefly describe some attempts to identify markers that could be detected in serum to be used to diagnose or monitor the disease without the need of a biopsy.
AB - Eosinophilic esophagitis is a chronic disease characterized by esophageal dysfunction, frequent clinical history of atopy, and eosinophilic inflammation of the esophagus. Within the esophageal mucosa, there is a wide variety of immune mediators, chemotactic factors, mediators of transcription, and markers of epithelial differentiation and integrity that are overexpressed or underexpressed in eosinophilic esophagitis, offering many candidates for biomarkers with diagnostic or prognostic potential. In this review, we summarize the results from studies performed so far to evaluate the detection of these markers by immunohistochemistry on esophageal biopsies. In addition, we briefly describe some attempts to identify markers that could be detected in serum to be used to diagnose or monitor the disease without the need of a biopsy.
KW - Eosinophilic esophagitis
KW - Gastroesophageal reflux
KW - Immunohistochemistry
UR - http://www.scopus.com/inward/record.url?scp=84994115533&partnerID=8YFLogxK
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U2 - 10.1097/PAI.0000000000000450
DO - 10.1097/PAI.0000000000000450
M3 - Review article
C2 - 27801733
AN - SCOPUS:84994115533
SN - 1541-2016
VL - 26
SP - 435
EP - 444
JO - Applied Immunohistochemistry and Molecular Morphology
JF - Applied Immunohistochemistry and Molecular Morphology
IS - 7
ER -