The inflammatory macrophage response to MCMV in mice with a retroviral immunodeficiency syndrome (MAIDS)

Richard J.N. Allcock, Craig D. Peacock, Patricia Price

Research output: Contribution to journalArticlepeer-review

Abstract

We have shown that normal C57BL/6J mice are moderately resistant to infection with murine cytomegalovirus (MCMV) and that this resistance is impaired by prior infection with LP-BM5 MuLV, which causes a disease (MAIDS) similar to early HIV-induced disease. This study investigates macrophage function in MAIDS+ mice challenged with MCMV. MAIDS reduces the influx of cells into the peritoneal cavity seen in normal C57BL/6J mice 6 days after MCMV infection. The infiltrates contained cells that resembled activated macrophages, as they took up colloidal gold, expressed the macrophage marker Mac-1, had high levels of acid phosphatase activity, and were lymphocytostatic when co-cultured with activated T cells. MAIDS+ mice had a higher percentage of cells able to take up colloidal gold and higher acid phosphatase activity per cell. The cells were also more lymphocytostatic and produced higher levels of interleukin-1 and tumor necrosis factor-α on days 4 and 6 after MCMV infection. Hence, MAIDS enhances baseline and induced macrophage activity, but depresses infiltration into the site of inflammation.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalJournal of Leukocyte Biology
Volume60
Issue number1
DOIs
StatePublished - Jul 1996

Keywords

  • Inflammation
  • Interleukin-1
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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