The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Alexandra Johnson Valiente; Kin Seng Liem; Kathleen B. Schwarz; Philip Rosenthal; Karen F. Murray; Douglas Mogul; Jeffery Teckman; Norberto Rodriguez-Baez; Sarah Jane Schwarzenberg; Jordan J. Feld; David K. Wong; Lia L. Lewis-Ximenez; Georg Lauer; Bettina E. Hansen; Simon C. Ling; Harry L.A. Janssen; Adam J. Gehring

doi:10.1093/infdis/jiab373

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Alexandra Johnson Valiente, Kin Seng Liem, Kathleen B. Schwarz, Philip Rosenthal, Karen F. Murray, Douglas Mogul, Jeffery Teckman, Norberto Rodriguez-Baez, Sarah Jane Schwarzenberg, Jordan J. Feld, David K. Wong, Lia L. Lewis-Ximenez, Georg Lauer, Bettina E. Hansen, Simon C. Ling, Harry L.A. Janssen, Adam J. Gehring

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

Original language	English (US)
Pages (from-to)	470-475
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	225
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiab373
State	Published - Feb 1 2022

Keywords

HBV
biomarker
chemokines
cytokines
flare
hepatitis B
immune response
inflammation
plasma

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/infdis/jiab373

Cite this

Johnson Valiente, A., Liem, K. S., Schwarz, K. B., Rosenthal, P., Murray, K. F., Mogul, D., Teckman, J., Rodriguez-Baez, N., Schwarzenberg, S. J., Feld, J. J., Wong, D. K., Lewis-Ximenez, L. L., Lauer, G., Hansen, B. E., Ling, S. C., Janssen, H. L. A., & Gehring, A. J. (2022). The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B. Journal of Infectious Diseases, 225(3), 470-475. https://doi.org/10.1093/infdis/jiab373

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B. / Johnson Valiente, Alexandra; Liem, Kin Seng; Schwarz, Kathleen B. et al.
In: Journal of Infectious Diseases, Vol. 225, No. 3, 01.02.2022, p. 470-475.

Research output: Contribution to journal › Article › peer-review

Johnson Valiente, A, Liem, KS, Schwarz, KB, Rosenthal, P, Murray, KF, Mogul, D, Teckman, J, Rodriguez-Baez, N, Schwarzenberg, SJ, Feld, JJ, Wong, DK, Lewis-Ximenez, LL, Lauer, G, Hansen, BE, Ling, SC, Janssen, HLA & Gehring, AJ 2022, 'The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B', Journal of Infectious Diseases, vol. 225, no. 3, pp. 470-475. https://doi.org/10.1093/infdis/jiab373

@article{6f0adbba9196403bb51f5e0336355ff8,

title = "The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B",

abstract = "Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.",

keywords = "HBV, biomarker, chemokines, cytokines, flare, hepatitis B, immune response, inflammation, plasma",

author = "{Johnson Valiente}, Alexandra and Liem, {Kin Seng} and Schwarz, {Kathleen B.} and Philip Rosenthal and Murray, {Karen F.} and Douglas Mogul and Jeffery Teckman and Norberto Rodriguez-Baez and Schwarzenberg, {Sarah Jane} and Feld, {Jordan J.} and Wong, {David K.} and Lewis-Ximenez, {Lia L.} and Georg Lauer and Hansen, {Bettina E.} and Ling, {Simon C.} and Janssen, {Harry L.A.} and Gehring, {Adam J.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",

year = "2022",

month = feb,

day = "1",

doi = "10.1093/infdis/jiab373",

language = "English (US)",

volume = "225",

pages = "470--475",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

AU - Johnson Valiente, Alexandra

AU - Liem, Kin Seng

AU - Schwarz, Kathleen B.

AU - Rosenthal, Philip

AU - Murray, Karen F.

AU - Mogul, Douglas

AU - Teckman, Jeffery

AU - Rodriguez-Baez, Norberto

AU - Schwarzenberg, Sarah Jane

AU - Feld, Jordan J.

AU - Wong, David K.

AU - Lewis-Ximenez, Lia L.

AU - Lauer, Georg

AU - Hansen, Bettina E.

AU - Ling, Simon C.

AU - Janssen, Harry L.A.

AU - Gehring, Adam J.

N1 - Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

AB - Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

KW - HBV

KW - biomarker

KW - chemokines

KW - cytokines

KW - flare

KW - hepatitis B

KW - immune response

KW - inflammation

KW - plasma

UR - http://www.scopus.com/inward/record.url?scp=85123968446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85123968446&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiab373

DO - 10.1093/infdis/jiab373

M3 - Article

C2 - 34286845

AN - SCOPUS:85123968446

SN - 0022-1899

VL - 225

SP - 470

EP - 475

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this