TY - JOUR
T1 - The infant microbiome development
T2 - Mom matters
AU - Mueller, Noel T.
AU - Bakacs, Elizabeth
AU - Combellick, Joan
AU - Grigoryan, Zoya
AU - Dominguez-Bello, Maria G.
N1 - Funding Information:
This work was partially supported by an anonymous grant (M.G.D-B.) and by the Emch Fund for Microbial Diversity (M.G.D-B.). N.T.M. received a fellowship from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK 5T32DK091227-03) to help complete this work.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - The infant microbiome plays an essential role in human health and its assembly is determined by maternal-offspring exchanges of microbiota. This process is affected by several practices, including Cesarean section (C-section), perinatal antibiotics, and formula feeding, that have been linked to increased risks of metabolic and immune diseases. Here we review recent knowledge about the impacts on infant microbiome assembly, discuss preventive and restorative strategies to ameliorate the effects of these impacts, and highlight where research is needed to advance this field and improve the health of future generations.
AB - The infant microbiome plays an essential role in human health and its assembly is determined by maternal-offspring exchanges of microbiota. This process is affected by several practices, including Cesarean section (C-section), perinatal antibiotics, and formula feeding, that have been linked to increased risks of metabolic and immune diseases. Here we review recent knowledge about the impacts on infant microbiome assembly, discuss preventive and restorative strategies to ameliorate the effects of these impacts, and highlight where research is needed to advance this field and improve the health of future generations.
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U2 - 10.1016/j.molmed.2014.12.002
DO - 10.1016/j.molmed.2014.12.002
M3 - Review article
C2 - 25578246
AN - SCOPUS:84922858726
SN - 1471-4914
VL - 21
SP - 109
EP - 117
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 2
ER -