Abstract
Regulatory T cells are known to play a role in the termination of the immune response. In this investigation, we bring evidence in support of the induction of antigen-specific regulatory cells in the thymus of the mouse. These thymus-derived regulatory cells depend upon injection with a high dose of antigen for their induction, appear in the thymus early after primary immunization (Days 7-12), are H-2- and strain-restricted in their action, and can by themselves suppress directly the secretion of antibodies from syngeneic antibody-forming cells in vitro. These regulatory cells, therefore, differ from previously reported murine suppressor T cells which exert their effect on antibody formation indirectly, generally by acting on helper T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 24-34 |
| Number of pages | 11 |
| Journal | Cellular Immunology |
| Volume | 116 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 1 1988 |
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ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
The induction of antigen-specific thymic regulatory cells in the mouse. / Talor, Eyal; Rose, Noel R.
In: Cellular Immunology, Vol. 116, No. 1, 01.10.1988, p. 24-34.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The induction of antigen-specific thymic regulatory cells in the mouse
AU - Talor, Eyal
AU - Rose, Noel R.
PY - 1988/10/1
Y1 - 1988/10/1
N2 - Regulatory T cells are known to play a role in the termination of the immune response. In this investigation, we bring evidence in support of the induction of antigen-specific regulatory cells in the thymus of the mouse. These thymus-derived regulatory cells depend upon injection with a high dose of antigen for their induction, appear in the thymus early after primary immunization (Days 7-12), are H-2- and strain-restricted in their action, and can by themselves suppress directly the secretion of antibodies from syngeneic antibody-forming cells in vitro. These regulatory cells, therefore, differ from previously reported murine suppressor T cells which exert their effect on antibody formation indirectly, generally by acting on helper T cells.
AB - Regulatory T cells are known to play a role in the termination of the immune response. In this investigation, we bring evidence in support of the induction of antigen-specific regulatory cells in the thymus of the mouse. These thymus-derived regulatory cells depend upon injection with a high dose of antigen for their induction, appear in the thymus early after primary immunization (Days 7-12), are H-2- and strain-restricted in their action, and can by themselves suppress directly the secretion of antibodies from syngeneic antibody-forming cells in vitro. These regulatory cells, therefore, differ from previously reported murine suppressor T cells which exert their effect on antibody formation indirectly, generally by acting on helper T cells.
UR - http://www.scopus.com/inward/record.url?scp=0023722828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023722828&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(88)90206-7
DO - 10.1016/0008-8749(88)90206-7
M3 - Article
C2 - 2971458
AN - SCOPUS:0023722828
VL - 116
SP - 24
EP - 34
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 1
ER -