Abstract
Regulatory T cells are known to play a role in the termination of the immune response. In this investigation, we bring evidence in support of the induction of antigen-specific regulatory cells in the thymus of the mouse. These thymus-derived regulatory cells depend upon injection with a high dose of antigen for their induction, appear in the thymus early after primary immunization (Days 7-12), are H-2- and strain-restricted in their action, and can by themselves suppress directly the secretion of antibodies from syngeneic antibody-forming cells in vitro. These regulatory cells, therefore, differ from previously reported murine suppressor T cells which exert their effect on antibody formation indirectly, generally by acting on helper T cells.
Original language | English (US) |
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Pages (from-to) | 24-34 |
Number of pages | 11 |
Journal | Cellular Immunology |
Volume | 116 |
Issue number | 1 |
DOIs | |
State | Published - Oct 1 1988 |
ASJC Scopus subject areas
- Immunology