The induction of antigen-specific thymic regulatory cells in the mouse

Eyal Talor, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

Regulatory T cells are known to play a role in the termination of the immune response. In this investigation, we bring evidence in support of the induction of antigen-specific regulatory cells in the thymus of the mouse. These thymus-derived regulatory cells depend upon injection with a high dose of antigen for their induction, appear in the thymus early after primary immunization (Days 7-12), are H-2- and strain-restricted in their action, and can by themselves suppress directly the secretion of antibodies from syngeneic antibody-forming cells in vitro. These regulatory cells, therefore, differ from previously reported murine suppressor T cells which exert their effect on antibody formation indirectly, generally by acting on helper T cells.

Original languageEnglish (US)
Pages (from-to)24-34
Number of pages11
JournalCellular Immunology
Volume116
Issue number1
DOIs
StatePublished - Oct 1 1988

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Thymus Gland
Antigens
Antibodies
Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Antibody Formation
Immunization
T-Lymphocytes
Injections
In Vitro Techniques

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

The induction of antigen-specific thymic regulatory cells in the mouse. / Talor, Eyal; Rose, Noel R.

In: Cellular Immunology, Vol. 116, No. 1, 01.10.1988, p. 24-34.

Research output: Contribution to journalArticle

Talor, Eyal ; Rose, Noel R. / The induction of antigen-specific thymic regulatory cells in the mouse. In: Cellular Immunology. 1988 ; Vol. 116, No. 1. pp. 24-34.
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