The independent and joint association of blood pressure, serum total homocysteine, and fasting serum glucose levels with brachial-ankle pulse wave velocity in chinese hypertensive adults: Associations of SBP, hcy and FBG with baPWV

Xiaoyun Liu, Ningling Sun, Tao Yu, Fangfang Fan, Meili Zheng, Geng Qian, Binyan Wang, Yu Wang, Genfu Tang, Jianping Li, Xianhui Qin, Fanfan Hou, Xiping Xu, Xinchun Yang, Yundai Chen, Xiaobin Wang, Yong Huo

Research output: Contribution to journalArticle

Abstract

This study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocity (baPWV, a measure of arterial stiffness) in Chinese hypertensive adults. The analyses included 3967 participants whose BP, Hcy, FBG, and baPWV were measured along with other covariates. Systolic BP (SBP) was analyzed as 3 categories (SBP < 160 mmHg; 160 to 179 mmHg; ≥ 180 mmHg); Hcy as 3 categories (< 10 μmol/L; 10 to 14.9 μmol/L; ≥ 15.0 μmol/L) and FBG: normal (FBG < 5.6 mmol/L), impaired (5.6 mmol/L ≤ FBG < 7.0 mmol/L), and diabetes mellitus (FBG ≥ 7.0 mmol/L). We performed linear regression analyses to evaluate their associations with baPWV with adjustment for covariables. When analyzed individually, BP, Hcy, and FBG were each associated with baPWV. When BP and FBG were analyzed jointly, the highest baPWV value (mean ± SD: 2227 ± 466 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and SBP ≥ 180 mmHg (β = 432.5, P < 0.001), and the lowest baPWV value (mean ± SD: 1692 ± 289 cm/s) was seen in participants with NFG and SBP < 160 mmHg. When Hcy and FBG were analyzed jointly, the highest baPWV value (2072 ± 480 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and Hcy ≥ 15.0 μmol/L (β = 167.6, P < 0.001), while the lowest baPWV value (mean ± SD: 1773 ± 334 cm/s) was observed in participants with NFG and Hcy < 10 μmol/L. In Chinese hypertensive adults, SBP, Hcy, and FBG are individually and jointly associated with baPWV. Our findings underscore the importance of identifying individuals with multiple risk factors of baPWV including high SBP, FBG, and Hcy.

Original languageEnglish (US)
Pages (from-to)627-633
Number of pages7
JournalInternational Heart Journal
Volume57
Issue number5
DOIs
StatePublished - 2016

Keywords

  • Arterial stiffness
  • Diabetes
  • Hypertension
  • MTHFR

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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