The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles

Pierre A. Coulombe, Michael Caterina

Research output: Contribution to journalArticle

Abstract

The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incompletely understood. In the June 1, 2013, issue of Genes & Development, Yucel and colleagues (pp. 1217- 1222) reported the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gated, L-type calcium channel, is expressed in hair follicle stem cells and contributes to anagen re-entry but does so in a calcium flux-independent fashion.

Original languageEnglish (US)
Pages (from-to)1315-1317
Number of pages3
JournalGenes & development
Volume27
Issue number12
DOIs
StatePublished - Jun 15 2013

Fingerprint

Hair Follicle
Stem Cells
L-Type Calcium Channels
Pluripotent Stem Cells
Hair
Epithelial Cells
Calcium
Skin
Genes

Keywords

  • Bulge
  • Calcium channel
  • Hair follicle stem cells
  • VGCC

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

The incidental pore : CaV1.2 and stem cell activation in quiescent hair follicles. / Coulombe, Pierre A.; Caterina, Michael.

In: Genes & development, Vol. 27, No. 12, 15.06.2013, p. 1315-1317.

Research output: Contribution to journalArticle

@article{1eb5e9fd38a442709a159c27f743dc0c,
title = "The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles",
abstract = "The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incompletely understood. In the June 1, 2013, issue of Genes & Development, Yucel and colleagues (pp. 1217- 1222) reported the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gated, L-type calcium channel, is expressed in hair follicle stem cells and contributes to anagen re-entry but does so in a calcium flux-independent fashion.",
keywords = "Bulge, Calcium channel, Hair follicle stem cells, VGCC",
author = "Coulombe, {Pierre A.} and Michael Caterina",
year = "2013",
month = "6",
day = "15",
doi = "10.1101/gad.223172.113",
language = "English (US)",
volume = "27",
pages = "1315--1317",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "12",

}

TY - JOUR

T1 - The incidental pore

T2 - CaV1.2 and stem cell activation in quiescent hair follicles

AU - Coulombe, Pierre A.

AU - Caterina, Michael

PY - 2013/6/15

Y1 - 2013/6/15

N2 - The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incompletely understood. In the June 1, 2013, issue of Genes & Development, Yucel and colleagues (pp. 1217- 1222) reported the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gated, L-type calcium channel, is expressed in hair follicle stem cells and contributes to anagen re-entry but does so in a calcium flux-independent fashion.

AB - The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incompletely understood. In the June 1, 2013, issue of Genes & Development, Yucel and colleagues (pp. 1217- 1222) reported the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gated, L-type calcium channel, is expressed in hair follicle stem cells and contributes to anagen re-entry but does so in a calcium flux-independent fashion.

KW - Bulge

KW - Calcium channel

KW - Hair follicle stem cells

KW - VGCC

UR - http://www.scopus.com/inward/record.url?scp=84879140873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879140873&partnerID=8YFLogxK

U2 - 10.1101/gad.223172.113

DO - 10.1101/gad.223172.113

M3 - Article

C2 - 23788620

AN - SCOPUS:84879140873

VL - 27

SP - 1315

EP - 1317

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 12

ER -