The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles

Pierre A. Coulombe, Michael J. Caterina

Research output: Contribution to journalArticlepeer-review

Abstract

The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incompletely understood. In the June 1, 2013, issue of Genes & Development, Yucel and colleagues (pp. 1217- 1222) reported the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gated, L-type calcium channel, is expressed in hair follicle stem cells and contributes to anagen re-entry but does so in a calcium flux-independent fashion.

Original languageEnglish (US)
Pages (from-to)1315-1317
Number of pages3
JournalGenes and Development
Volume27
Issue number12
DOIs
StatePublished - Jun 15 2013

Keywords

  • Bulge
  • Calcium channel
  • Hair follicle stem cells
  • VGCC

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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