The Incidence of Ulcerative Keratitis among Users of Daily-Wear and Extended-Wear Soft Contact Lenses

Eugene C. Poggio, Robert J. Glynn, Oliver D. Schein, Johanna M. Seddon, Maura J. Shannon, Vincent A. Scardino, Kenneth R. Kenyon

Research output: Contribution to journalArticlepeer-review

Abstract

The wearing of contact lenses has increased dramatically in the past decade; over 4 million people in the United States now use extended-wear soft contact lenses, and 9 million use daily-wear soft contact lenses. Numerous reports have caused concern that the use of soft contact lenses, especially extended-wear lenses, may result in a substantial risk of ulcerative keratitis. To examine this issue, we conducted a prospective study in five New England states to estimate the incidence of ulcerative keratitis among those who use cosmetic extended-wear and daily-wear soft contact lenses. To obtain the numerator for each estimate of incidence, we surveyed all practicing ophthalmologists in the study area to identify all new cases diagnosed over a four-month period. To provide the denominator, we conducted a survey of 4178 households to estimate the number of persons who wore each type of soft contact lens. The annualized incidence of ulcerative keratitis was estimated to be 20.9 per 10,000 persons using extended-wear soft contact lenses for cosmetic purposes and 4.1 per 10,000 persons using daily-wear soft contact lenses for cosmetic purposes (P<0.00001). (N Engl J Med 1989; 321:779-83.) IN 1987 the Food and Drug Administration estimated that 18.2 million Americans wore contact lenses. 1Of this number, approximately 9.1 million use daily-wear lenses and 4.1 million use extended-wear lenses, which are approved for overnight use. The majority wear soft, hydrophilic contact lenses for cosmetic, refractive purposes. The most serious adverse effect of wearing contact lenses is ulcerative keratitis, a condition that can be associated with a permanent loss of vision. Ulcerative keratitis is an ulceration of the corneal epithelium with an underlying inflammation of the corneal stroma. In patients who wear contact lenses, the process is presumed to be. . .

Original languageEnglish (US)
Pages (from-to)779-783
Number of pages5
JournalNew England Journal of Medicine
Volume321
Issue number12
DOIs
StatePublished - Sep 21 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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