The Incidence of p53 Mutations Increases with Progression of Head and Neck Cancer

Jay O. Boyle, John Hakim, Wayne Koch, Peter van der Riet, Ralph H. Hruban, R. Arturo Roa, Russell Correo, Yolanda J. Eby, J. Michael Ruppert, David Sidransky

Research output: Contribution to journalArticle

Abstract

To establish a genetic model of the progression of head and neck squamous carcinoma we have defined the incidence and timing of pS3 mutations in this type of cancer. We sequenced the conserved regions of the p53 gene in 102 head and neck squamous carcinoma lesions. These included 65 primary invasive carcinomas and 37 noninvasive archival specimens consisting of 13 severe dysplasias and 24 carcinoma in situ lesions. The incidence of p53 mutations in noninvasive lesions was 19% (7/37) and increased to 43% (28/65) in invasive carcinomas. These data suggest that p53 mutations can precede invasion in primary head and neck cancer. Furthermore, the spectrum of codon hotspots is similar to that seen in squamous carcinoma of the lung and 64% of mutations are at G nucleotides, implicating carcinogens from tobacco smoke in the etiology of head and neck squamous carcinoma.

Original languageEnglish (US)
Pages (from-to)4477-4480
Number of pages4
JournalCancer Research
Volume53
Issue number19
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Boyle, J. O., Hakim, J., Koch, W., van der Riet, P., Hruban, R. H., Roa, R. A., Correo, R., Eby, Y. J., Ruppert, J. M., & Sidransky, D. (1993). The Incidence of p53 Mutations Increases with Progression of Head and Neck Cancer. Cancer Research, 53(19), 4477-4480.