The incidence and course of retinopathy of prematurity

Findings from the early treatment for retinopathy of prematurity study

Early Treatment for Retinopathy of Prematurity Cooperative Group

Research output: Contribution to journalArticle

Abstract

Objectives. To estimate the incidence of retinopathy of prematurity (ROP) in the Early Treatment for Retinopathy of Prematurity (ETROP) Study and compare these results with those reported in the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) Study. Methods. The ETROP Study, as part of its protocol, screened 6998 infants at 26 centers throughout the United States. Serial eye examinations were conducted for infants born weighing <1251 g, making it possible to estimate the frequency of ROP in different birth weight and gestational age categories. ROP was categorized according to the International Classification for ROP. Results. The incidence of any ROP was 68% among infants of <1251 g. The findings were compared with those for infants born in 1986 and 1987 in the CRYO-ROP Study. The overall incidences of ROP were similar in the 2 studies, but there was more zone I ROP in the ETROP Study. Among infants with ROP, more-severe ROP (prethreshold) occurred for 36.9% of infants in the ETROP Study and 27.1% of infants in the CRYO-ROP Study. The gestational age of onset of ROP of different severities has changed very little since the CRYO-ROP Study was conducted. Conclusions. ROP remains a common important problem among infants with birth weights of <1251 g. The incidence of ROP, time of onset, rate of progression, and time of onset of prethreshold disease have changed little since the CRYO-ROP natural-history study.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalPediatrics
Volume116
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Retinopathy of Prematurity
Incidence
Cryotherapy
Therapeutics
Birth Weight
Gestational Age

Keywords

  • Incidence
  • Retinopathy of prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The incidence and course of retinopathy of prematurity : Findings from the early treatment for retinopathy of prematurity study. / Early Treatment for Retinopathy of Prematurity Cooperative Group.

In: Pediatrics, Vol. 116, No. 1, 01.01.2005, p. 15-23.

Research output: Contribution to journalArticle

Early Treatment for Retinopathy of Prematurity Cooperative Group. / The incidence and course of retinopathy of prematurity : Findings from the early treatment for retinopathy of prematurity study. In: Pediatrics. 2005 ; Vol. 116, No. 1. pp. 15-23.
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title = "The incidence and course of retinopathy of prematurity: Findings from the early treatment for retinopathy of prematurity study",
abstract = "Objectives. To estimate the incidence of retinopathy of prematurity (ROP) in the Early Treatment for Retinopathy of Prematurity (ETROP) Study and compare these results with those reported in the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) Study. Methods. The ETROP Study, as part of its protocol, screened 6998 infants at 26 centers throughout the United States. Serial eye examinations were conducted for infants born weighing <1251 g, making it possible to estimate the frequency of ROP in different birth weight and gestational age categories. ROP was categorized according to the International Classification for ROP. Results. The incidence of any ROP was 68{\%} among infants of <1251 g. The findings were compared with those for infants born in 1986 and 1987 in the CRYO-ROP Study. The overall incidences of ROP were similar in the 2 studies, but there was more zone I ROP in the ETROP Study. Among infants with ROP, more-severe ROP (prethreshold) occurred for 36.9{\%} of infants in the ETROP Study and 27.1{\%} of infants in the CRYO-ROP Study. The gestational age of onset of ROP of different severities has changed very little since the CRYO-ROP Study was conducted. Conclusions. ROP remains a common important problem among infants with birth weights of <1251 g. The incidence of ROP, time of onset, rate of progression, and time of onset of prethreshold disease have changed little since the CRYO-ROP natural-history study.",
keywords = "Incidence, Retinopathy of prematurity",
author = "{Early Treatment for Retinopathy of Prematurity Cooperative Group} and Good, {William V.} and Hardy, {R. J.} and V. Dobson and Palmer, {E. A.} and Phelps, {D. L.} and M. Quintos and B. Tung and A. Madan and M. Ball and Hall, {J. Y.} and J. Gancasz and D. Durand and T. Slagle and G. Smith and M. Shapiro and N. Santiago and R. Bhat and L. Kaufman and M. Miller and D. Mittelman and D. Neely and Hynes, {E. A.} and D. Plager and Barr, {C. C.} and M. Bottorff and Whittington, {G. K.} and Fishman, {P. H.} and Rychwalski, {P. J.} and Gordon, {R. A.} and Neff, {D. S.} and Diamond, {J. G.} and Gill, {W. L.} and Preslan, {M. W.} and K. Powdrill and Hutcheson, {K. A.} and E. Jones and Steidl, {S. M.} and Waeltermann, {J. M.} and Repka, {Michael X} and Shepard, {J. A.} and P. Donahue and Aucott, {Susan W} and Collins, {M. L.} and Maureen Gilmore and James Handa and VanderVeen, {D. K.} and T. Mansfield and B. MacKinnon and Cole, {C. H.} and A. Fraioli",
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TY - JOUR

T1 - The incidence and course of retinopathy of prematurity

T2 - Findings from the early treatment for retinopathy of prematurity study

AU - Early Treatment for Retinopathy of Prematurity Cooperative Group

AU - Good, William V.

AU - Hardy, R. J.

AU - Dobson, V.

AU - Palmer, E. A.

AU - Phelps, D. L.

AU - Quintos, M.

AU - Tung, B.

AU - Madan, A.

AU - Ball, M.

AU - Hall, J. Y.

AU - Gancasz, J.

AU - Durand, D.

AU - Slagle, T.

AU - Smith, G.

AU - Shapiro, M.

AU - Santiago, N.

AU - Bhat, R.

AU - Kaufman, L.

AU - Miller, M.

AU - Mittelman, D.

AU - Neely, D.

AU - Hynes, E. A.

AU - Plager, D.

AU - Barr, C. C.

AU - Bottorff, M.

AU - Whittington, G. K.

AU - Fishman, P. H.

AU - Rychwalski, P. J.

AU - Gordon, R. A.

AU - Neff, D. S.

AU - Diamond, J. G.

AU - Gill, W. L.

AU - Preslan, M. W.

AU - Powdrill, K.

AU - Hutcheson, K. A.

AU - Jones, E.

AU - Steidl, S. M.

AU - Waeltermann, J. M.

AU - Repka, Michael X

AU - Shepard, J. A.

AU - Donahue, P.

AU - Aucott, Susan W

AU - Collins, M. L.

AU - Gilmore, Maureen

AU - Handa, James

AU - VanderVeen, D. K.

AU - Mansfield, T.

AU - MacKinnon, B.

AU - Cole, C. H.

AU - Fraioli, A.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Objectives. To estimate the incidence of retinopathy of prematurity (ROP) in the Early Treatment for Retinopathy of Prematurity (ETROP) Study and compare these results with those reported in the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) Study. Methods. The ETROP Study, as part of its protocol, screened 6998 infants at 26 centers throughout the United States. Serial eye examinations were conducted for infants born weighing <1251 g, making it possible to estimate the frequency of ROP in different birth weight and gestational age categories. ROP was categorized according to the International Classification for ROP. Results. The incidence of any ROP was 68% among infants of <1251 g. The findings were compared with those for infants born in 1986 and 1987 in the CRYO-ROP Study. The overall incidences of ROP were similar in the 2 studies, but there was more zone I ROP in the ETROP Study. Among infants with ROP, more-severe ROP (prethreshold) occurred for 36.9% of infants in the ETROP Study and 27.1% of infants in the CRYO-ROP Study. The gestational age of onset of ROP of different severities has changed very little since the CRYO-ROP Study was conducted. Conclusions. ROP remains a common important problem among infants with birth weights of <1251 g. The incidence of ROP, time of onset, rate of progression, and time of onset of prethreshold disease have changed little since the CRYO-ROP natural-history study.

AB - Objectives. To estimate the incidence of retinopathy of prematurity (ROP) in the Early Treatment for Retinopathy of Prematurity (ETROP) Study and compare these results with those reported in the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) Study. Methods. The ETROP Study, as part of its protocol, screened 6998 infants at 26 centers throughout the United States. Serial eye examinations were conducted for infants born weighing <1251 g, making it possible to estimate the frequency of ROP in different birth weight and gestational age categories. ROP was categorized according to the International Classification for ROP. Results. The incidence of any ROP was 68% among infants of <1251 g. The findings were compared with those for infants born in 1986 and 1987 in the CRYO-ROP Study. The overall incidences of ROP were similar in the 2 studies, but there was more zone I ROP in the ETROP Study. Among infants with ROP, more-severe ROP (prethreshold) occurred for 36.9% of infants in the ETROP Study and 27.1% of infants in the CRYO-ROP Study. The gestational age of onset of ROP of different severities has changed very little since the CRYO-ROP Study was conducted. Conclusions. ROP remains a common important problem among infants with birth weights of <1251 g. The incidence of ROP, time of onset, rate of progression, and time of onset of prethreshold disease have changed little since the CRYO-ROP natural-history study.

KW - Incidence

KW - Retinopathy of prematurity

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DO - 10.1542/peds.2004-1413

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