The in vivo stability of the tritium label in 1,2-H3d-aldo-sterone when used for measurement of aldosterone secretion rate by the double isotope dilution technique.

Avinoam Kowarski; Jordan Finkelstein; Bernadette Loras; Claude J. Migeon

doi:10.1016/0039-128X(64)90055-8

The in vivo stability of the tritium label in 1,2-H³d-aldo-sterone when used for measurement of aldosterone secretion rate by the double isotope dilution technique.

Avinoam Kowarski, Jordan Finkelstein, Bernadette Loras, Claude J. Migeon

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The in vivo stability of the tritium label in 1,2-H³-d-aldosterone has been demonstrated in two totally adrenalectomized patients. It is concluded that this radioactive preparation is suitable for the measurement of aldosterone secretion rate in man. It is suggested that when using the method of Kliman and Peterson, two paper chromatographies should be carried out after pH 1 hydrolysis, acetylation and oxidation.

Original language	English (US)
Pages (from-to)	95-107
Number of pages	13
Journal	Steroids
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0039-128X(64)90055-8
State	Published - Jan 1964
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/0039-128X(64)90055-8

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abstract = "The in vivo stability of the tritium label in 1,2-H3-d-aldosterone has been demonstrated in two totally adrenalectomized patients. It is concluded that this radioactive preparation is suitable for the measurement of aldosterone secretion rate in man. It is suggested that when using the method of Kliman and Peterson, two paper chromatographies should be carried out after pH 1 hydrolysis, acetylation and oxidation.",

author = "Avinoam Kowarski and Jordan Finkelstein and Bernadette Loras and Migeon, {Claude J.}",

year = "1964",

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AU - Kowarski, Avinoam

AU - Finkelstein, Jordan

AU - Loras, Bernadette

AU - Migeon, Claude J.

PY - 1964/1

Y1 - 1964/1

N2 - The in vivo stability of the tritium label in 1,2-H3-d-aldosterone has been demonstrated in two totally adrenalectomized patients. It is concluded that this radioactive preparation is suitable for the measurement of aldosterone secretion rate in man. It is suggested that when using the method of Kliman and Peterson, two paper chromatographies should be carried out after pH 1 hydrolysis, acetylation and oxidation.

AB - The in vivo stability of the tritium label in 1,2-H3-d-aldosterone has been demonstrated in two totally adrenalectomized patients. It is concluded that this radioactive preparation is suitable for the measurement of aldosterone secretion rate in man. It is suggested that when using the method of Kliman and Peterson, two paper chromatographies should be carried out after pH 1 hydrolysis, acetylation and oxidation.

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The in vivo stability of the tritium label in 1,2-H³d-aldo-sterone when used for measurement of aldosterone secretion rate by the double isotope dilution technique.

Abstract

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