The in vivo stability of the tritium label in 1,2-H3d-aldo-sterone when used for measurement of aldosterone secretion rate by the double isotope dilution technique.

Avinoam Kowarski, Jordan Finkelstein, Bernadette Loras, Claude J. Migeon

Research output: Contribution to journalArticlepeer-review

Abstract

The in vivo stability of the tritium label in 1,2-H3-d-aldosterone has been demonstrated in two totally adrenalectomized patients. It is concluded that this radioactive preparation is suitable for the measurement of aldosterone secretion rate in man. It is suggested that when using the method of Kliman and Peterson, two paper chromatographies should be carried out after pH 1 hydrolysis, acetylation and oxidation.

Original languageEnglish (US)
Pages (from-to)95-107
Number of pages13
JournalSteroids
Volume3
Issue number1
DOIs
StatePublished - Jan 1964

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'The in vivo stability of the tritium label in 1,2-H<sup>3</sup>d-aldo-sterone when used for measurement of aldosterone secretion rate by the double isotope dilution technique.'. Together they form a unique fingerprint.

Cite this