The in vitro effects of a novel vascular protectant, AGI-1067, on platelet aggregation and major receptor expression in subjects with multiple risk factors for vascular disease

Victor Serebruany, Alex Malinin, Robert Scott

Research output: Contribution to journalArticle

Abstract

Oxidation-sensitive signals are important in platelet activation. The novel, phenolic, intracellular and extracellular antioxidant AGI-1067 inhibits the expression of a number of proinflammatory genes involved in atherosclerosis. The effect of AGI-1067 on human platelets was evaluated. Blood obtained from 20 aspirin-naïve volunteers with multiple risk factors for vascular disease was preincubated with escalating concentrations of AGI-1067 for the assessment of its ex vivo effects on platelet aggregation and expression of major surface receptors flow cytometry, evaluated by flow cytometry. AGI-1067 resulted in significant inhibition of a variety of activation-dependent platelet biomarkers in healthy volunteers, including adenosine diphosphate-induced platelet aggregation and decreased surface platelet expression of glycoprotein IIb/IIIa antigen, activity with PAC-1 antibody, and glycoprotein Ib (CD42b). The effect of AGI-1067 differs from other known antiplatelet agents, suggesting opportunities for therapeutic combination. These data need to be confirmed in subjects receiving orally dosed AGI-1067 to be clinically relevant.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume11
Issue number3
DOIs
StatePublished - Sep 2006

Keywords

  • Antioxidants
  • Coronary artery disease
  • Platelets

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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