The importance of IGHV mutational status in del(11q) and del(17p) chronic lymphocytic leukemia

Douglas E. Gladstone, Amanda Blackford, Eunpi Cho, Lode Swinnen, Yvette Kasamon, Christopher D. Gocke, Constance A. Griffin, Javier Bolaños-Meade, Richard J. Jones

Research output: Contribution to journalArticle

Abstract

Background: Most patients with CLL with a poor-risk cytogenetic profile have an unmutated IGHV sequence. Limited clinical information exists for patients with CLL who have a poor-risk cytogenetic profile and a mutated or good-risk IGHV status. We retrospectively screened all patients with CLL seen at our institution from 2006 onward who harbored a del(11q) or del(17p) CLL detected by fluorescence in situ hybridization (FISH) analysis for whom an IGHV analysis was requested. In 66 evaluable patients, 50 (76%) had an unmutated IGHV sequence. Thirty-nine patients (59%) had del(11q) and 27 patients (41%) had del(17p); no patient in this series had both del(11q) and del(17p). The patients' initial clinical presentations were similar in both mutational groups. Patients with an unmutated IGHV sequence were more likely to receive treatment and to have a shorter survival, with an estimated 3-year overall survival (OS) of 81% compared with 100% in the group with a mutated IGHV sequence (log rank, P = .06). These data suggest that IGHV mutational status has prognostic relevance even in patients with CLL who are defined as poor risk by genomic FISH analysis.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalClinical Lymphoma, Myeloma and Leukemia
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2012

Keywords

  • CLL
  • Clinical outcomes
  • IGHV
  • del(11q)
  • del(17p)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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