@article{c56a7b1b5c4541b0aca4db8eafb412aa,
title = "The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes",
abstract = "A surprising finding of recent studies in mouse is the dominance of widespread movement-related activity throughout the brain, including in early sensory areas. In awake subjects, failing to account for movement risks misattributing movement-related activity to other (e.g., sensory or cognitive) processes. In this article, we (1) review task designs for separating task-related and movement-related activity, (2) review three “case studies” in which not considering movement would have resulted in critically different interpretations of neuronal function, and (3) discuss functional couplings that may prevent us from ever fully isolating sensory, motor, and cognitive-related activity. Our main thesis is that neural signals related to movement are ubiquitous, and therefore ought to be considered first and foremost when attempting to correlate neuronal activity with task-related processes.",
keywords = "behavior, cognition, movement, neural coding, sensorimotor",
author = "Edward Zagha and Erlich, {Jeffrey C.} and Soohyun Lee and Gyorgy Lur and O{\textquoteright}Connor, {Daniel H.} and Steinmetz, {Nicholas A.} and Carsen Stringer and Hongdian Yang",
note = "Funding Information: Received Sep. 23, 2021; revised Dec. 2, 2021; accepted Dec. 29, 2021. This work was supported by National Institutes of Health Grants R01NS107599 to E.Z., R01MH123686 to G.L., R01NS104834 to D.H.O., and R01NS107355 and R01NS112200 to H.Y.; Intramural Research Program of National Institute of Mental Health, National Institutes of Health ZIAMH002959 to S.L.; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai and the 111 Project, Base B16018 to J.C.E.; Klingenstein-Simons Foundation to N.A.S. and H.Y.; Pew Biomedical Scholars program to N.A.S.; and Howard Hughes Medical Institute to C.S. We thank members of the E.Z. laboratory for helpful comments on the manuscript. The authors declare no competing financial interests. Correspondence should be addressed to Edward Zagha at edward.zagha@ucr.edu or Hongdian Yang at hongdian@ucr.edu. https://doi.org/10.1523/JNEUROSCI.1919-21.2021 Copyright {\textcopyright} 2022 the authors Publisher Copyright: Copyright {\textcopyright} 2022 the authors",
year = "2022",
month = feb,
day = "23",
doi = "10.1523/JNEUROSCI.1919-21.2021",
language = "English (US)",
volume = "42",
pages = "1375--1382",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "8",
}