The implications of the ezetimibe and simvastatin in hypercholesterolemia enhances atherosclerosis regression trial: A return to first principles

Kiran Musunuru; Roger S. Blumenthal

doi:10.1002/clc.20405

The implications of the ezetimibe and simvastatin in hypercholesterolemia enhances atherosclerosis regression trial: A return to first principles

Kiran Musunuru, Roger S. Blumenthal

School of Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

To outward appearances, the publication of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial has led to a monolithic backlash against the use of ezetimibe by cardiologists for the treatment of hyperlipidemia. Rather than be swayed by popular opinion, we should each put the results of ENHANCE into context and ask the questions: should I put my trust in an imaging surrogate or in low-density lipoprotein (LDL) cholesterol (LDL-C), and how do the safety and efficacy of ezetimibe compare with other nonstatin lipid-lowering agents?

Original language	English (US)
Pages (from-to)	288-290
Number of pages	3
Journal	Clinical Cardiology
Volume	31
Issue number	6
DOIs	https://doi.org/10.1002/clc.20405
State	Published - Jun 2008

Keywords

ENHANCE trial
Ezetimibe
Hypercholesterolemia

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1002/clc.20405

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abstract = "To outward appearances, the publication of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial has led to a monolithic backlash against the use of ezetimibe by cardiologists for the treatment of hyperlipidemia. Rather than be swayed by popular opinion, we should each put the results of ENHANCE into context and ask the questions: should I put my trust in an imaging surrogate or in low-density lipoprotein (LDL) cholesterol (LDL-C), and how do the safety and efficacy of ezetimibe compare with other nonstatin lipid-lowering agents?",

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AB - To outward appearances, the publication of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial has led to a monolithic backlash against the use of ezetimibe by cardiologists for the treatment of hyperlipidemia. Rather than be swayed by popular opinion, we should each put the results of ENHANCE into context and ask the questions: should I put my trust in an imaging surrogate or in low-density lipoprotein (LDL) cholesterol (LDL-C), and how do the safety and efficacy of ezetimibe compare with other nonstatin lipid-lowering agents?

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The implications of the ezetimibe and simvastatin in hypercholesterolemia enhances atherosclerosis regression trial: A return to first principles

Abstract

Keywords

ASJC Scopus subject areas

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