Abstract
The stringent criteria required for a clinically applicable automatic ventricular defibrillator have now been satisfied. The hermetically sealed unit is encased in titanium, weighs 250 g, and occupies a volume of 145 cc. Continously monitoring cardiac electrical activity, the device detects ventricular fibrillation when isoelectric potential segments disappear and restore normal rhythm with a truncated exponential pulse of 30 joules delivered 15 seconds after onset of the dysrhythmia. The operational status of the defibrillator can be tested noninvasively in vivo with an external analyzer. Functional performance of the device has been evaluated in nonanesthetized, active animals by inducing ventricular fibrillation with a specially designed implanted fibrillator. The resulting syncope mimics the clinical entity of sudden death, but in contrast to stricken patients, the animals are automatically defibrillated and resuscitated with the implanted defibrillator. Pilot clinical studies of this approach to prevention of sudden death from ventricular fibrillation are scheduled to begin in the near future.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 851-859 |
| Number of pages | 9 |
| Journal | Cardiovascular Medicine |
| Volume | 4 |
| Issue number | 8 |
| State | Published - 1979 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The implantable automatic defibrillator. / Mirowski, M.; Mower, Morton Maimon; Bhagavan, Belur.
In: Cardiovascular Medicine, Vol. 4, No. 8, 1979, p. 851-859.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The implantable automatic defibrillator
AU - Mirowski, M.
AU - Mower, Morton Maimon
AU - Bhagavan, Belur
PY - 1979
Y1 - 1979
N2 - The stringent criteria required for a clinically applicable automatic ventricular defibrillator have now been satisfied. The hermetically sealed unit is encased in titanium, weighs 250 g, and occupies a volume of 145 cc. Continously monitoring cardiac electrical activity, the device detects ventricular fibrillation when isoelectric potential segments disappear and restore normal rhythm with a truncated exponential pulse of 30 joules delivered 15 seconds after onset of the dysrhythmia. The operational status of the defibrillator can be tested noninvasively in vivo with an external analyzer. Functional performance of the device has been evaluated in nonanesthetized, active animals by inducing ventricular fibrillation with a specially designed implanted fibrillator. The resulting syncope mimics the clinical entity of sudden death, but in contrast to stricken patients, the animals are automatically defibrillated and resuscitated with the implanted defibrillator. Pilot clinical studies of this approach to prevention of sudden death from ventricular fibrillation are scheduled to begin in the near future.
AB - The stringent criteria required for a clinically applicable automatic ventricular defibrillator have now been satisfied. The hermetically sealed unit is encased in titanium, weighs 250 g, and occupies a volume of 145 cc. Continously monitoring cardiac electrical activity, the device detects ventricular fibrillation when isoelectric potential segments disappear and restore normal rhythm with a truncated exponential pulse of 30 joules delivered 15 seconds after onset of the dysrhythmia. The operational status of the defibrillator can be tested noninvasively in vivo with an external analyzer. Functional performance of the device has been evaluated in nonanesthetized, active animals by inducing ventricular fibrillation with a specially designed implanted fibrillator. The resulting syncope mimics the clinical entity of sudden death, but in contrast to stricken patients, the animals are automatically defibrillated and resuscitated with the implanted defibrillator. Pilot clinical studies of this approach to prevention of sudden death from ventricular fibrillation are scheduled to begin in the near future.
UR - http://www.scopus.com/inward/record.url?scp=0018682860&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018682860&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0018682860
VL - 4
SP - 851
EP - 859
JO - Cardiovascular Medicine
JF - Cardiovascular Medicine
SN - 0199-6614
IS - 8
ER -