The impacts of severe perfusion defects, akinetic/dyskinetic segments, and viable myocardium on the accuracy of volumes and LVEF measured by gated 99mTc-MIBI SPECT and gated 18F-FDG PET in patients with left ventricular aneurysm: cardiac magnetic resonance imaging as the reference

Hongxing Wei, Congna Tian, Thomas H. Schindler, Mei Qiu, Minjie Lu, Rui Shen, Yueqin Tian, Shi hua Zhao, Xiaoli Zhang

Research output: Contribution to journalArticle

Abstract

Background: To compare the accuracy of end-diastolic and end-systolic volumes (EDV, ESV) and LV ejection fraction (LVEF) measured by both GSPECT and GPET, using cardiac magnetic resonance imaging (CMR) as a reference. Furthermore, the impacts of severe perfusion defects, akinetic/dyskinetic segments, and residual viable myocardium on the accuracy of LV functional parameters were investigated.

Methods: Ninety-six consecutive patients with LV aneurysm and LV dysfunction (LVEF 32 ± 9%) diagnosed by CMR were studied with GSPECT and GPET. EDV, ESV, and LVEF were calculated using QGS software.

Results: Correlations of volumes were excellent (r 0.81-0.86) and correlation of LVEF was moderate (r 0.65-0.76) between GSPECT vs CMR and between GPET vs CMR. Compared with CMR, ESV was overestimated by GSPECT (P 

Conclusions: In LV aneurysm patients, LV volumes and LVEF measured by both GSPECT and GPET imaging correlated well with those determined by CMR, but should not be interchangeable in individual patients. The accuracy of LVEF measured by GSPECT and GPET was affected by the akinetic/dyskinetic segments with absent WT.

Original languageEnglish (US)
Pages (from-to)1230-1244
Number of pages15
JournalJournal of Nuclear Cardiology
Volume21
Issue number6
DOIs
StatePublished - 2014

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Heart Aneurysm
Fluorodeoxyglucose F18
Single-Photon Emission-Computed Tomography
Myocardium
Perfusion
Magnetic Resonance Imaging
Aneurysm
Software

Keywords

  • Aneurysm
  • cardiovascular MRI
  • ejection fraction
  • gated <sup>18</sup>F-FDG PET
  • gated <sup>99m</sup>Tc-sestamibi SPECT

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

The impacts of severe perfusion defects, akinetic/dyskinetic segments, and viable myocardium on the accuracy of volumes and LVEF measured by gated 99mTc-MIBI SPECT and gated 18F-FDG PET in patients with left ventricular aneurysm : cardiac magnetic resonance imaging as the reference. / Wei, Hongxing; Tian, Congna; Schindler, Thomas H.; Qiu, Mei; Lu, Minjie; Shen, Rui; Tian, Yueqin; Zhao, Shi hua; Zhang, Xiaoli.

In: Journal of Nuclear Cardiology, Vol. 21, No. 6, 2014, p. 1230-1244.

Research output: Contribution to journalArticle

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title = "The impacts of severe perfusion defects, akinetic/dyskinetic segments, and viable myocardium on the accuracy of volumes and LVEF measured by gated 99mTc-MIBI SPECT and gated 18F-FDG PET in patients with left ventricular aneurysm: cardiac magnetic resonance imaging as the reference",
abstract = "Background: To compare the accuracy of end-diastolic and end-systolic volumes (EDV, ESV) and LV ejection fraction (LVEF) measured by both GSPECT and GPET, using cardiac magnetic resonance imaging (CMR) as a reference. Furthermore, the impacts of severe perfusion defects, akinetic/dyskinetic segments, and residual viable myocardium on the accuracy of LV functional parameters were investigated.Methods: Ninety-six consecutive patients with LV aneurysm and LV dysfunction (LVEF 32 ± 9{\%}) diagnosed by CMR were studied with GSPECT and GPET. EDV, ESV, and LVEF were calculated using QGS software.Results: Correlations of volumes were excellent (r 0.81-0.86) and correlation of LVEF was moderate (r 0.65-0.76) between GSPECT vs CMR and between GPET vs CMR. Compared with CMR, ESV was overestimated by GSPECT (P Conclusions: In LV aneurysm patients, LV volumes and LVEF measured by both GSPECT and GPET imaging correlated well with those determined by CMR, but should not be interchangeable in individual patients. The accuracy of LVEF measured by GSPECT and GPET was affected by the akinetic/dyskinetic segments with absent WT.",
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T1 - The impacts of severe perfusion defects, akinetic/dyskinetic segments, and viable myocardium on the accuracy of volumes and LVEF measured by gated 99mTc-MIBI SPECT and gated 18F-FDG PET in patients with left ventricular aneurysm

T2 - cardiac magnetic resonance imaging as the reference

AU - Wei, Hongxing

AU - Tian, Congna

AU - Schindler, Thomas H.

AU - Qiu, Mei

AU - Lu, Minjie

AU - Shen, Rui

AU - Tian, Yueqin

AU - Zhao, Shi hua

AU - Zhang, Xiaoli

PY - 2014

Y1 - 2014

N2 - Background: To compare the accuracy of end-diastolic and end-systolic volumes (EDV, ESV) and LV ejection fraction (LVEF) measured by both GSPECT and GPET, using cardiac magnetic resonance imaging (CMR) as a reference. Furthermore, the impacts of severe perfusion defects, akinetic/dyskinetic segments, and residual viable myocardium on the accuracy of LV functional parameters were investigated.Methods: Ninety-six consecutive patients with LV aneurysm and LV dysfunction (LVEF 32 ± 9%) diagnosed by CMR were studied with GSPECT and GPET. EDV, ESV, and LVEF were calculated using QGS software.Results: Correlations of volumes were excellent (r 0.81-0.86) and correlation of LVEF was moderate (r 0.65-0.76) between GSPECT vs CMR and between GPET vs CMR. Compared with CMR, ESV was overestimated by GSPECT (P Conclusions: In LV aneurysm patients, LV volumes and LVEF measured by both GSPECT and GPET imaging correlated well with those determined by CMR, but should not be interchangeable in individual patients. The accuracy of LVEF measured by GSPECT and GPET was affected by the akinetic/dyskinetic segments with absent WT.

AB - Background: To compare the accuracy of end-diastolic and end-systolic volumes (EDV, ESV) and LV ejection fraction (LVEF) measured by both GSPECT and GPET, using cardiac magnetic resonance imaging (CMR) as a reference. Furthermore, the impacts of severe perfusion defects, akinetic/dyskinetic segments, and residual viable myocardium on the accuracy of LV functional parameters were investigated.Methods: Ninety-six consecutive patients with LV aneurysm and LV dysfunction (LVEF 32 ± 9%) diagnosed by CMR were studied with GSPECT and GPET. EDV, ESV, and LVEF were calculated using QGS software.Results: Correlations of volumes were excellent (r 0.81-0.86) and correlation of LVEF was moderate (r 0.65-0.76) between GSPECT vs CMR and between GPET vs CMR. Compared with CMR, ESV was overestimated by GSPECT (P Conclusions: In LV aneurysm patients, LV volumes and LVEF measured by both GSPECT and GPET imaging correlated well with those determined by CMR, but should not be interchangeable in individual patients. The accuracy of LVEF measured by GSPECT and GPET was affected by the akinetic/dyskinetic segments with absent WT.

KW - Aneurysm

KW - cardiovascular MRI

KW - ejection fraction

KW - gated <sup>18</sup>F-FDG PET

KW - gated <sup>99m</sup>Tc-sestamibi SPECT

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