The impact that group sequential tests would have made on ECOG clinical trials

Gary L. Rosner; Anastasios A. Tsiatis

doi:10.1002/sim.4780080413

The impact that group sequential tests would have made on ECOG clinical trials

Gary L. Rosner, Anastasios A. Tsiatis

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Using designs that several authors proposed, we reanalysed a large number of completed phase III clinical trials of the Eastern Cooperative Oncology Group as if each had been designed with group sequential stopping rules. With survival the primary endpoint of the large multicentre trials, we discuss the relative merits of each design, as well as the feasibility of group sequential designs in general.

Original language	English (US)
Pages (from-to)	505-516
Number of pages	12
Journal	Statistics in Medicine
Volume	8
Issue number	4
DOIs	https://doi.org/10.1002/sim.4780080413
State	Published - Apr 1989
Externally published	Yes

Keywords

Repeated significance tests
Score test
Sequential analysis
Survival analysis

ASJC Scopus subject areas

Epidemiology
Statistics and Probability

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10.1002/sim.4780080413

Cite this

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KW - Survival analysis

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The impact that group sequential tests would have made on ECOG clinical trials

Abstract

Keywords

ASJC Scopus subject areas

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