The impact that group sequential tests would have made on ECOG clinical trials

Gary L. Rosner, Anastasios A. Tsiatis

Research output: Contribution to journalArticlepeer-review

Abstract

Using designs that several authors proposed, we reanalysed a large number of completed phase III clinical trials of the Eastern Cooperative Oncology Group as if each had been designed with group sequential stopping rules. With survival the primary endpoint of the large multicentre trials, we discuss the relative merits of each design, as well as the feasibility of group sequential designs in general.

Original languageEnglish (US)
Pages (from-to)505-516
Number of pages12
JournalStatistics in Medicine
Volume8
Issue number4
DOIs
StatePublished - Apr 1989
Externally publishedYes

Keywords

  • Repeated significance tests
  • Score test
  • Sequential analysis
  • Survival analysis

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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