The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma

Maris S. Jones, Peter C. Jones, Stacey L. Stern, David Elashoff, Dave S.B. Hoon, John Thompson, Nicola Mozzillo, Omgo E. Nieweg, Dirk Noyes, Harald J. Hoekstra, Jonathan S. Zager, Daniel F. Roses, Alessandro Testori, Brendon J. Coventry, Mark B. Smithers, Robert Andtbacka, Doreen Agnese, Erwin Schultz, Eddy C. Hsueh, Mark Kelley & 6 others Schlomo Schneebaum, Lisa Jacobs, Tawnya Bowles, Mohammed Kashani-Sabet, Douglas Johnson, Mark B. Faries

Research output: Contribution to journalArticle

Abstract

Background: Although a well-established causative relationship exists between smoking and several epithelial cancers, the association of smoking with metastatic progression in melanoma is not well studied. We hypothesized that smokers would be at increased risk for melanoma metastasis as assessed by sentinel lymph node (SLN) biopsy. Methods: Data from the first international Multicenter Selective Lymphadenectomy Trial (MSLT-I) and the screening-phase of the second trial (MSLT-II) were analyzed to determine the association of smoking with clinicopathologic variables and SLN metastasis. Results: Current smoking was strongly associated with SLN metastasis (p = 0.004), even after adjusting for other predictors of metastasis. Among 4231 patients (1025 in MSLT-I and 3206 in MSLT-II), current or former smoking was also independently associated with ulceration (p < 0.001 and p < 0.001, respectively). Compared with current smoking, never smoking was independently associated with decreased Breslow thickness in multivariate analysis (p = 0.002) and with a 0.25 mm predicted decrease in thickness. Conclusion: The direct correlation between current smoking and SLN metastasis of primary cutaneous melanoma was independent of its correlation with tumor thickness and ulceration. Smoking cessation should be strongly encouraged among patients with or at risk for melanoma.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalAnnals of Surgical Oncology
DOIs
StateAccepted/In press - Feb 21 2017

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Melanoma
Smoking
Neoplasm Metastasis
Skin
Lymph Node Excision
Sentinel Lymph Node Biopsy
cyhalothrin
Smoking Cessation
Neoplasms
Multivariate Analysis
Sentinel Lymph Node

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Jones, M. S., Jones, P. C., Stern, S. L., Elashoff, D., Hoon, D. S. B., Thompson, J., ... Faries, M. B. (Accepted/In press). The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma. Annals of Surgical Oncology, 1-6. https://doi.org/10.1245/s10434-017-5775-9

The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma. / Jones, Maris S.; Jones, Peter C.; Stern, Stacey L.; Elashoff, David; Hoon, Dave S.B.; Thompson, John; Mozzillo, Nicola; Nieweg, Omgo E.; Noyes, Dirk; Hoekstra, Harald J.; Zager, Jonathan S.; Roses, Daniel F.; Testori, Alessandro; Coventry, Brendon J.; Smithers, Mark B.; Andtbacka, Robert; Agnese, Doreen; Schultz, Erwin; Hsueh, Eddy C.; Kelley, Mark; Schneebaum, Schlomo; Jacobs, Lisa; Bowles, Tawnya; Kashani-Sabet, Mohammed; Johnson, Douglas; Faries, Mark B.

In: Annals of Surgical Oncology, 21.02.2017, p. 1-6.

Research output: Contribution to journalArticle

Jones, MS, Jones, PC, Stern, SL, Elashoff, D, Hoon, DSB, Thompson, J, Mozzillo, N, Nieweg, OE, Noyes, D, Hoekstra, HJ, Zager, JS, Roses, DF, Testori, A, Coventry, BJ, Smithers, MB, Andtbacka, R, Agnese, D, Schultz, E, Hsueh, EC, Kelley, M, Schneebaum, S, Jacobs, L, Bowles, T, Kashani-Sabet, M, Johnson, D & Faries, MB 2017, 'The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma', Annals of Surgical Oncology, pp. 1-6. https://doi.org/10.1245/s10434-017-5775-9
Jones, Maris S. ; Jones, Peter C. ; Stern, Stacey L. ; Elashoff, David ; Hoon, Dave S.B. ; Thompson, John ; Mozzillo, Nicola ; Nieweg, Omgo E. ; Noyes, Dirk ; Hoekstra, Harald J. ; Zager, Jonathan S. ; Roses, Daniel F. ; Testori, Alessandro ; Coventry, Brendon J. ; Smithers, Mark B. ; Andtbacka, Robert ; Agnese, Doreen ; Schultz, Erwin ; Hsueh, Eddy C. ; Kelley, Mark ; Schneebaum, Schlomo ; Jacobs, Lisa ; Bowles, Tawnya ; Kashani-Sabet, Mohammed ; Johnson, Douglas ; Faries, Mark B. / The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma. In: Annals of Surgical Oncology. 2017 ; pp. 1-6.
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abstract = "Background: Although a well-established causative relationship exists between smoking and several epithelial cancers, the association of smoking with metastatic progression in melanoma is not well studied. We hypothesized that smokers would be at increased risk for melanoma metastasis as assessed by sentinel lymph node (SLN) biopsy. Methods: Data from the first international Multicenter Selective Lymphadenectomy Trial (MSLT-I) and the screening-phase of the second trial (MSLT-II) were analyzed to determine the association of smoking with clinicopathologic variables and SLN metastasis. Results: Current smoking was strongly associated with SLN metastasis (p = 0.004), even after adjusting for other predictors of metastasis. Among 4231 patients (1025 in MSLT-I and 3206 in MSLT-II), current or former smoking was also independently associated with ulceration (p < 0.001 and p < 0.001, respectively). Compared with current smoking, never smoking was independently associated with decreased Breslow thickness in multivariate analysis (p = 0.002) and with a 0.25 mm predicted decrease in thickness. Conclusion: The direct correlation between current smoking and SLN metastasis of primary cutaneous melanoma was independent of its correlation with tumor thickness and ulceration. Smoking cessation should be strongly encouraged among patients with or at risk for melanoma.",
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T1 - The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma

AU - Jones, Maris S.

AU - Jones, Peter C.

AU - Stern, Stacey L.

AU - Elashoff, David

AU - Hoon, Dave S.B.

AU - Thompson, John

AU - Mozzillo, Nicola

AU - Nieweg, Omgo E.

AU - Noyes, Dirk

AU - Hoekstra, Harald J.

AU - Zager, Jonathan S.

AU - Roses, Daniel F.

AU - Testori, Alessandro

AU - Coventry, Brendon J.

AU - Smithers, Mark B.

AU - Andtbacka, Robert

AU - Agnese, Doreen

AU - Schultz, Erwin

AU - Hsueh, Eddy C.

AU - Kelley, Mark

AU - Schneebaum, Schlomo

AU - Jacobs, Lisa

AU - Bowles, Tawnya

AU - Kashani-Sabet, Mohammed

AU - Johnson, Douglas

AU - Faries, Mark B.

PY - 2017/2/21

Y1 - 2017/2/21

N2 - Background: Although a well-established causative relationship exists between smoking and several epithelial cancers, the association of smoking with metastatic progression in melanoma is not well studied. We hypothesized that smokers would be at increased risk for melanoma metastasis as assessed by sentinel lymph node (SLN) biopsy. Methods: Data from the first international Multicenter Selective Lymphadenectomy Trial (MSLT-I) and the screening-phase of the second trial (MSLT-II) were analyzed to determine the association of smoking with clinicopathologic variables and SLN metastasis. Results: Current smoking was strongly associated with SLN metastasis (p = 0.004), even after adjusting for other predictors of metastasis. Among 4231 patients (1025 in MSLT-I and 3206 in MSLT-II), current or former smoking was also independently associated with ulceration (p < 0.001 and p < 0.001, respectively). Compared with current smoking, never smoking was independently associated with decreased Breslow thickness in multivariate analysis (p = 0.002) and with a 0.25 mm predicted decrease in thickness. Conclusion: The direct correlation between current smoking and SLN metastasis of primary cutaneous melanoma was independent of its correlation with tumor thickness and ulceration. Smoking cessation should be strongly encouraged among patients with or at risk for melanoma.

AB - Background: Although a well-established causative relationship exists between smoking and several epithelial cancers, the association of smoking with metastatic progression in melanoma is not well studied. We hypothesized that smokers would be at increased risk for melanoma metastasis as assessed by sentinel lymph node (SLN) biopsy. Methods: Data from the first international Multicenter Selective Lymphadenectomy Trial (MSLT-I) and the screening-phase of the second trial (MSLT-II) were analyzed to determine the association of smoking with clinicopathologic variables and SLN metastasis. Results: Current smoking was strongly associated with SLN metastasis (p = 0.004), even after adjusting for other predictors of metastasis. Among 4231 patients (1025 in MSLT-I and 3206 in MSLT-II), current or former smoking was also independently associated with ulceration (p < 0.001 and p < 0.001, respectively). Compared with current smoking, never smoking was independently associated with decreased Breslow thickness in multivariate analysis (p = 0.002) and with a 0.25 mm predicted decrease in thickness. Conclusion: The direct correlation between current smoking and SLN metastasis of primary cutaneous melanoma was independent of its correlation with tumor thickness and ulceration. Smoking cessation should be strongly encouraged among patients with or at risk for melanoma.

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