Abstract
Objective: To determine if sarcopenia modulates the response to a physical activity intervention in functionally limited older adults. Design: Secondary analysis of a randomized controlled trial. Setting: Three academic centers. Participants: Elders aged 70 to 89 years at risk for mobility disability who underwent dualenergy x-ray absorptiometry (DXA) for body composition at enrollment and follow-up at twelve months (N = 177). Intervention: Subjects participated in a physical activity program (PA) featuring aerobic, strength, balance, and flexibility training, or a successful aging (SA) educational program about healthy aging. Measurements: Sarcopenia as determined by measuring appendicular lean mass and adjusting for height and total body fat mass (residuals method), Short Physical Performance Battery score (SPPB), and gait speed determined on 400 meter course. Results: At twelve months, sarcopenic and non-sarcopenic subjects in PA tended to have higher mean SPPB scores (8.7±0.5 and 8.7±0.2 points) compared to sarcopenic and non-sarcopenic subjects in SA (8.3±0.5 and 8.4±0.2 points, p = 0.24 and 0.10), although the differences were not statistically significant. At twelve months, faster mean gait speeds were observed in PA: 0.93±0.4 and 0.95±0.03 meters/second in sarcopenic and non-sarcopenic PA subjects, and 0.89±0.4 and 0.91±0.03 meters/second in sarcopenic and non-sarcopenic SA subjects (p = 0.98 and 0.26), although not statistically significant. There was no difference between the sarcopenic and non-sarcopenic groups in intervention adherence or number of adverse events. Conclusion: These data suggest that older adults with sarcopenia, who represent a vulnerable segment of the elder population, are capable of improvements in physical performance after a physical activity intervention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 59-64 |
| Number of pages | 6 |
| Journal | The journal of nutrition, health & aging |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2014 |
| Externally published | Yes |
Fingerprint
Keywords
- gait speed
- Key word: Sarcopenia
- physical activity
- short physical performance battery
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Geriatrics and Gerontology
Cite this
The impact of sarcopenia on a physical activity intervention : The lifestyle interventions and independence for elders pilot study (LIFE-P). / Liu, Christine K.; Leng, X.; Hsu, F. C.; Kritchevsky, S. B.; Ding, J.; Earnest, C. P.; Ferrucci, L.; Goodpaster, B. H.; Guralnik, J. M.; Lenchik, L.; Pahor, M.; Fielding, R. A.
In: The journal of nutrition, health & aging, Vol. 18, No. 1, 01.2014, p. 59-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The impact of sarcopenia on a physical activity intervention
T2 - The lifestyle interventions and independence for elders pilot study (LIFE-P)
AU - Liu, Christine K.
AU - Leng, X.
AU - Hsu, F. C.
AU - Kritchevsky, S. B.
AU - Ding, J.
AU - Earnest, C. P.
AU - Ferrucci, L.
AU - Goodpaster, B. H.
AU - Guralnik, J. M.
AU - Lenchik, L.
AU - Pahor, M.
AU - Fielding, R. A.
PY - 2014/1
Y1 - 2014/1
N2 - Objective: To determine if sarcopenia modulates the response to a physical activity intervention in functionally limited older adults. Design: Secondary analysis of a randomized controlled trial. Setting: Three academic centers. Participants: Elders aged 70 to 89 years at risk for mobility disability who underwent dualenergy x-ray absorptiometry (DXA) for body composition at enrollment and follow-up at twelve months (N = 177). Intervention: Subjects participated in a physical activity program (PA) featuring aerobic, strength, balance, and flexibility training, or a successful aging (SA) educational program about healthy aging. Measurements: Sarcopenia as determined by measuring appendicular lean mass and adjusting for height and total body fat mass (residuals method), Short Physical Performance Battery score (SPPB), and gait speed determined on 400 meter course. Results: At twelve months, sarcopenic and non-sarcopenic subjects in PA tended to have higher mean SPPB scores (8.7±0.5 and 8.7±0.2 points) compared to sarcopenic and non-sarcopenic subjects in SA (8.3±0.5 and 8.4±0.2 points, p = 0.24 and 0.10), although the differences were not statistically significant. At twelve months, faster mean gait speeds were observed in PA: 0.93±0.4 and 0.95±0.03 meters/second in sarcopenic and non-sarcopenic PA subjects, and 0.89±0.4 and 0.91±0.03 meters/second in sarcopenic and non-sarcopenic SA subjects (p = 0.98 and 0.26), although not statistically significant. There was no difference between the sarcopenic and non-sarcopenic groups in intervention adherence or number of adverse events. Conclusion: These data suggest that older adults with sarcopenia, who represent a vulnerable segment of the elder population, are capable of improvements in physical performance after a physical activity intervention.
AB - Objective: To determine if sarcopenia modulates the response to a physical activity intervention in functionally limited older adults. Design: Secondary analysis of a randomized controlled trial. Setting: Three academic centers. Participants: Elders aged 70 to 89 years at risk for mobility disability who underwent dualenergy x-ray absorptiometry (DXA) for body composition at enrollment and follow-up at twelve months (N = 177). Intervention: Subjects participated in a physical activity program (PA) featuring aerobic, strength, balance, and flexibility training, or a successful aging (SA) educational program about healthy aging. Measurements: Sarcopenia as determined by measuring appendicular lean mass and adjusting for height and total body fat mass (residuals method), Short Physical Performance Battery score (SPPB), and gait speed determined on 400 meter course. Results: At twelve months, sarcopenic and non-sarcopenic subjects in PA tended to have higher mean SPPB scores (8.7±0.5 and 8.7±0.2 points) compared to sarcopenic and non-sarcopenic subjects in SA (8.3±0.5 and 8.4±0.2 points, p = 0.24 and 0.10), although the differences were not statistically significant. At twelve months, faster mean gait speeds were observed in PA: 0.93±0.4 and 0.95±0.03 meters/second in sarcopenic and non-sarcopenic PA subjects, and 0.89±0.4 and 0.91±0.03 meters/second in sarcopenic and non-sarcopenic SA subjects (p = 0.98 and 0.26), although not statistically significant. There was no difference between the sarcopenic and non-sarcopenic groups in intervention adherence or number of adverse events. Conclusion: These data suggest that older adults with sarcopenia, who represent a vulnerable segment of the elder population, are capable of improvements in physical performance after a physical activity intervention.
KW - gait speed
KW - Key word: Sarcopenia
KW - physical activity
KW - short physical performance battery
UR - http://www.scopus.com/inward/record.url?scp=84893878163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893878163&partnerID=8YFLogxK
U2 - 10.1007/s12603-013-0369-0
DO - 10.1007/s12603-013-0369-0
M3 - Article
C2 - 24402391
AN - SCOPUS:84893878163
VL - 18
SP - 59
EP - 64
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
SN - 1279-7707
IS - 1
ER -