The impact of respiratory and cardiac effects on the phase and magnitude of resting-state fMRI signal

Zikuan Chen, Vince Calhoun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional magnetic resonance imaging (fMRI) relies on detecting small changes in signal during brain activities, in presence of various noise, including those caused by respiration and cardiac pulsation. In the resting state, there is no explicit task event except the baseline neuroactivities of awakeness and other unknowns. However, the resting state is accompanied with the cardiac and respiration pulsations, which are the explicit non-neuronal physiological sources of fMRI signals. By recording the respiration and cardiac waveforms in synchrony with the fMRI scanning, we may estimate the physiological modulation artifacts in the fMRI dataset by the temporal correlations between the waveforms and the fMRI signal. In this work, we demonstrate that the respiration and cardiac modulation effects on the magnitude and phase components of the complex fMRI signal, including temporal correlation and time latency. In particular, our results show that: 1) the fMRI phase is slightly more modulated by the physiological modulations than its magnitude counterpart; 2) the fMRI signal (both magnitude and phase) shows 1 to 2s latency to respiration stimulus, and 0 to 1s latency to cardiac stimulus. For physiological artifact removal, we compare the band-stop filtering method with the RETROICOR method and find the former can remove the physiological modulations in a stable and consistent manner in frequency domain (stopping the signature frequencies irrespective of asynchrony.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2011
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - May 16 2011
Externally publishedYes
EventMedical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 13 2011Feb 16 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7965
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/13/112/16/11

Keywords

  • Band-stop filtering
  • Cardiac pulsation
  • Physiological modulation
  • RETROICOR
  • Respiration
  • Temporal correlation
  • Time latency
  • fMRI

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Chen, Z., & Calhoun, V. (2011). The impact of respiratory and cardiac effects on the phase and magnitude of resting-state fMRI signal. In Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging [79652A] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7965). https://doi.org/10.1117/12.877321