The impact of policies to restrict the use of plasma containing products and apheresis platelets from female donors to mitigate transfusion related acute lung injury (TRALI) in Brazil

Paula Fraiman Blatyta, Brian Custer, Jing Liu, Alfredo Mendrone-Junior, David J. Wright, Silvana Carneiro Leão, Maria Inês Lopes, Anna Bárbara Carneiro-Proietti, Ester Cerdeira Sabino, Cesar de Almeida-Neto

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: Although the incidence of TRALI is unknown in Brazil, some blood centers have adopted strategies to prevent TRALI. We evaluated the impact of three policies to mitigate TRALI on the supply of blood products: to divert the production of whole blood-derived plasma from female donors; to defer all female donors from apheresis platelet collections, and to defer only multiparous female donors from apheresis platelet collections. Materials and Methods: Data from allogeneic whole blood and apheresis platelet donations from April 2008 to December 2009 were collected in three Brazilian blood centers and the impact of the aforementioned strategies was evaluated. Results: Of 544,814 allogeneic blood donations, 30.8% of whole blood plasma and 24.1% of apheresis platelet donations would be reduced if only male donor plasma was issued for transfusion and all female donors were deferred from apheresis donation, respectively. If only multiparous donors were deferred from apheresis donation, there would be a 5% decrease of all apheresis platelet collections. Conclusion: Restricting the use of whole blood derived plasma to male-only donors and deferring all female apheresis platelet donors would impact two out of three Brazilian blood centers. A deferral policy on multiparous apheresis platelet donors may be acceptable as a temporary measure, but may cause more stress on a system that is already working at its limit.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalTransfusion and Apheresis Science
Volume48
Issue number1
DOIs
StatePublished - Feb 2013

Keywords

  • Apheresis platelets
  • Brazil
  • Leukocyte antibodies
  • Multiparous donors
  • TRALI
  • Transfusion reactions

ASJC Scopus subject areas

  • Hematology

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