TY - JOUR
T1 - The impact of policies to restrict the use of plasma containing products and apheresis platelets from female donors to mitigate transfusion related acute lung injury (TRALI) in Brazil
AU - Blatyta, Paula Fraiman
AU - Custer, Brian
AU - Liu, Jing
AU - Mendrone-Junior, Alfredo
AU - Wright, David J.
AU - Leão, Silvana Carneiro
AU - Lopes, Maria Inês
AU - Carneiro-Proietti, Anna Bárbara
AU - Sabino, Ester Cerdeira
AU - de Almeida-Neto, Cesar
N1 - Funding Information:
Supported by the National Heart Lung and Blood Institute, National Institutes of Health, Retrovirus Epidemiology Donor Study-II: International Component. REDS-II Publications Committee approved this manuscript to be submitted for publication.
PY - 2013/2
Y1 - 2013/2
N2 - Background and Objectives: Although the incidence of TRALI is unknown in Brazil, some blood centers have adopted strategies to prevent TRALI. We evaluated the impact of three policies to mitigate TRALI on the supply of blood products: to divert the production of whole blood-derived plasma from female donors; to defer all female donors from apheresis platelet collections, and to defer only multiparous female donors from apheresis platelet collections. Materials and Methods: Data from allogeneic whole blood and apheresis platelet donations from April 2008 to December 2009 were collected in three Brazilian blood centers and the impact of the aforementioned strategies was evaluated. Results: Of 544,814 allogeneic blood donations, 30.8% of whole blood plasma and 24.1% of apheresis platelet donations would be reduced if only male donor plasma was issued for transfusion and all female donors were deferred from apheresis donation, respectively. If only multiparous donors were deferred from apheresis donation, there would be a 5% decrease of all apheresis platelet collections. Conclusion: Restricting the use of whole blood derived plasma to male-only donors and deferring all female apheresis platelet donors would impact two out of three Brazilian blood centers. A deferral policy on multiparous apheresis platelet donors may be acceptable as a temporary measure, but may cause more stress on a system that is already working at its limit.
AB - Background and Objectives: Although the incidence of TRALI is unknown in Brazil, some blood centers have adopted strategies to prevent TRALI. We evaluated the impact of three policies to mitigate TRALI on the supply of blood products: to divert the production of whole blood-derived plasma from female donors; to defer all female donors from apheresis platelet collections, and to defer only multiparous female donors from apheresis platelet collections. Materials and Methods: Data from allogeneic whole blood and apheresis platelet donations from April 2008 to December 2009 were collected in three Brazilian blood centers and the impact of the aforementioned strategies was evaluated. Results: Of 544,814 allogeneic blood donations, 30.8% of whole blood plasma and 24.1% of apheresis platelet donations would be reduced if only male donor plasma was issued for transfusion and all female donors were deferred from apheresis donation, respectively. If only multiparous donors were deferred from apheresis donation, there would be a 5% decrease of all apheresis platelet collections. Conclusion: Restricting the use of whole blood derived plasma to male-only donors and deferring all female apheresis platelet donors would impact two out of three Brazilian blood centers. A deferral policy on multiparous apheresis platelet donors may be acceptable as a temporary measure, but may cause more stress on a system that is already working at its limit.
KW - Apheresis platelets
KW - Brazil
KW - Leukocyte antibodies
KW - Multiparous donors
KW - TRALI
KW - Transfusion reactions
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U2 - 10.1016/j.transci.2012.07.010
DO - 10.1016/j.transci.2012.07.010
M3 - Article
C2 - 22985535
AN - SCOPUS:84873147193
SN - 1473-0502
VL - 48
SP - 15
EP - 20
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 1
ER -