Abstract
Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 217-226 |
| Number of pages | 10 |
| Journal | Journal of Clinical and Experimental Neuropsychology |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 7 2016 |
Keywords
- Huntington disease
- Neuropsychology
- Oculomotor functioning
- PREDICT-HD
- Processing speed
ASJC Scopus subject areas
- Clinical Psychology
- Neurology
- Clinical Neurology
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The impact of oculomotor functioning on neuropsychological performance in Huntington disease. / Carvalho, Janessa O.; Long, Jeffrey D.; Westervelt, Holly J.; Smith, Megan M.; Bruce, Jared M.; Kim, Ji In; Mills, James A.; Paulsen, Jane S.; De Soriano, Isabella; Shadrick, Courtney; Miller, Amanda; Chiu, Edmond; Preston, Joy; Goh, Anita; Antonopoulos, Stephanie; Loi, Samantha; Chua, Phyllis; Komiti, Angela; Raymond, Lynn; Decolongon, Joji; Fan, Mannie; Coleman, Allison; Ross, Christopher A.; Varvaris, Mark; Ong, Maryjane; Yoritomo, Nadine; Mallonee, William M.; Suter, Greg; Samii, Ali; Freney, Emily P.; Macaraeg, Alma; Jones, Randi; Wood-Siverio, Cathy; Factor, Stewart A.; Barker, Roger A.; Mason, Sarah; Guzman, Natalie Valle; McCusker, Elizabeth; Griffith, Jane; Loy, Clement; McMillan, Jillian; Gunn, David; Orth, Michael; Süßmuth, Sigurd; Barth, Katrin; Trautmann, Sonja; Schwenk, Daniela; Eschenbach, Carolin; Quaid, Kimberly; Wesson, Melissa; Wojcieszek, Joanne; Guttman, Mark; Sheinberg, Alanna; Law, Albie; Karmalkar, Irita; Perlman, Susan; Clemente, Brian; Geschwind, Michael D.; Sha, Sharon; Winer, Joseph; Satris, Gabriela; Warner, Tom; Burrows, Maggie; Rosser, Anne; Price, Kathy; Hunt, Sarah; Marshall, Frederick; Chesire, Amy; Wodarski, Mary; Hickey, Charlyne; Panegyres, Peter; Lee, Joseph; Tedesco, Maria; Maxwell, Brenton; Perlmutter, Joel; Barton, Stacey; Smith, Shineeka; Miedzybrodzka, Zosia; Rae, Daniela; Vaughan, Vivien; D'Alessandro, Mariella; Craufurd, David; Bek, Judith; Howard, Elizabeth; Mazzoni, Pietro; Marder, Karen; Wasserman, Paula; Kumar, Rajeev; Erickson, Diane; Reeves, Christina; Nickels, Breanna; Wheelock, Vicki; Kjer, Lisa; Martin, Amanda; Farias, Sarah; Martin, Wayne; Suchowersky, Oksana; King, Pamela; Wieler, Marguerite; Sran, Satwinder; Ahmed, Anwar; Rao, Stephen; Reece, Christine; Bura, Alex; Mourany, Lyla; Danzer, Phil; Montross, Kelsey; Harrington, Deborah; Westervalt, Holly; Aylward, Elizabeth; Moser, David J.; Williams, Janet; Downing, Nancy; Magnotta, Vincent A.; Johnson, Hans J.; Brashers-Krug, Thomas; Vaidya, Jatin; O'Leary, Daniel; Young Kim, Eun; Lourens, Spencer; Zhang, Ying; Lu, Wenjing; Erwin, Cheryl; Nance, Martha; Bockholt, H. Jeremy; Evans, Jason; Zschiegner, Roland.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 38, No. 2, 07.02.2016, p. 217-226.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The impact of oculomotor functioning on neuropsychological performance in Huntington disease
AU - Carvalho, Janessa O.
AU - Long, Jeffrey D.
AU - Westervelt, Holly J.
AU - Smith, Megan M.
AU - Bruce, Jared M.
AU - Kim, Ji In
AU - Mills, James A.
AU - Paulsen, Jane S.
AU - De Soriano, Isabella
AU - Shadrick, Courtney
AU - Miller, Amanda
AU - Chiu, Edmond
AU - Preston, Joy
AU - Goh, Anita
AU - Antonopoulos, Stephanie
AU - Loi, Samantha
AU - Chua, Phyllis
AU - Komiti, Angela
AU - Raymond, Lynn
AU - Decolongon, Joji
AU - Fan, Mannie
AU - Coleman, Allison
AU - Ross, Christopher A.
AU - Varvaris, Mark
AU - Ong, Maryjane
AU - Yoritomo, Nadine
AU - Mallonee, William M.
AU - Suter, Greg
AU - Samii, Ali
AU - Freney, Emily P.
AU - Macaraeg, Alma
AU - Jones, Randi
AU - Wood-Siverio, Cathy
AU - Factor, Stewart A.
AU - Barker, Roger A.
AU - Mason, Sarah
AU - Guzman, Natalie Valle
AU - McCusker, Elizabeth
AU - Griffith, Jane
AU - Loy, Clement
AU - McMillan, Jillian
AU - Gunn, David
AU - Orth, Michael
AU - Süßmuth, Sigurd
AU - Barth, Katrin
AU - Trautmann, Sonja
AU - Schwenk, Daniela
AU - Eschenbach, Carolin
AU - Quaid, Kimberly
AU - Wesson, Melissa
AU - Wojcieszek, Joanne
AU - Guttman, Mark
AU - Sheinberg, Alanna
AU - Law, Albie
AU - Karmalkar, Irita
AU - Perlman, Susan
AU - Clemente, Brian
AU - Geschwind, Michael D.
AU - Sha, Sharon
AU - Winer, Joseph
AU - Satris, Gabriela
AU - Warner, Tom
AU - Burrows, Maggie
AU - Rosser, Anne
AU - Price, Kathy
AU - Hunt, Sarah
AU - Marshall, Frederick
AU - Chesire, Amy
AU - Wodarski, Mary
AU - Hickey, Charlyne
AU - Panegyres, Peter
AU - Lee, Joseph
AU - Tedesco, Maria
AU - Maxwell, Brenton
AU - Perlmutter, Joel
AU - Barton, Stacey
AU - Smith, Shineeka
AU - Miedzybrodzka, Zosia
AU - Rae, Daniela
AU - Vaughan, Vivien
AU - D'Alessandro, Mariella
AU - Craufurd, David
AU - Bek, Judith
AU - Howard, Elizabeth
AU - Mazzoni, Pietro
AU - Marder, Karen
AU - Wasserman, Paula
AU - Kumar, Rajeev
AU - Erickson, Diane
AU - Reeves, Christina
AU - Nickels, Breanna
AU - Wheelock, Vicki
AU - Kjer, Lisa
AU - Martin, Amanda
AU - Farias, Sarah
AU - Martin, Wayne
AU - Suchowersky, Oksana
AU - King, Pamela
AU - Wieler, Marguerite
AU - Sran, Satwinder
AU - Ahmed, Anwar
AU - Rao, Stephen
AU - Reece, Christine
AU - Bura, Alex
AU - Mourany, Lyla
AU - Danzer, Phil
AU - Montross, Kelsey
AU - Harrington, Deborah
AU - Westervalt, Holly
AU - Aylward, Elizabeth
AU - Moser, David J.
AU - Williams, Janet
AU - Downing, Nancy
AU - Magnotta, Vincent A.
AU - Johnson, Hans J.
AU - Brashers-Krug, Thomas
AU - Vaidya, Jatin
AU - O'Leary, Daniel
AU - Young Kim, Eun
AU - Lourens, Spencer
AU - Zhang, Ying
AU - Lu, Wenjing
AU - Erwin, Cheryl
AU - Nance, Martha
AU - Bockholt, H. Jeremy
AU - Evans, Jason
AU - Zschiegner, Roland
N1 - Funding Information: We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington''s Disease Society of America, and the Huntington Study Group. This work was supported by the National Institutes for Health, National Institute of Neurological Disorders and Stroke [grant number 5R01NS040068] awarded to Jane Paulsen; CHDI Foundation, Inc. [grant number A6266], [grant number A2015] awarded to Jane Paulsen; and Cognitive and Functional Brain Changes in Preclinical Huntington''s Disease (HD) [grant number R01NS054893] awarded to Jane Paulsen. Publisher Copyright: © 2016 Taylor & Francis.
PY - 2016/2/7
Y1 - 2016/2/7
N2 - Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.
AB - Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.
KW - Huntington disease
KW - Neuropsychology
KW - Oculomotor functioning
KW - PREDICT-HD
KW - Processing speed
UR - http://www.scopus.com/inward/record.url?scp=84954062766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954062766&partnerID=8YFLogxK
U2 - 10.1080/13803395.2015.1101054
DO - 10.1080/13803395.2015.1101054
M3 - Article
C2 - 26745770
AN - SCOPUS:84954062766
VL - 38
SP - 217
EP - 226
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
SN - 1380-3395
IS - 2
ER -