The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Janessa O. Carvalho; Jeffrey D. Long; Holly J. Westervelt; Megan M. Smith; Jared M. Bruce; Ji In Kim; James A. Mills; Jane S. Paulsen; Isabella De Soriano; Courtney Shadrick; Amanda Miller; Edmond Chiu; Joy Preston; Anita Goh; Stephanie Antonopoulos; Samantha Loi; Phyllis Chua; Angela Komiti; Lynn Raymond; Joji Decolongon; Mannie Fan; Allison Coleman; Christopher A. Ross; Mark Varvaris; Maryjane Ong; Nadine Yoritomo; William M. Mallonee; Greg Suter; Ali Samii; Emily P. Freney; Alma Macaraeg; Randi Jones; Cathy Wood-Siverio; Stewart A. Factor; Roger A. Barker; Sarah Mason; Natalie Valle Guzman; Elizabeth McCusker; Jane Griffith; Clement Loy; Jillian McMillan; David Gunn; Michael Orth; Sigurd Süßmuth; Katrin Barth; Sonja Trautmann; Daniela Schwenk; Carolin Eschenbach; Kimberly Quaid; Melissa Wesson; Joanne Wojcieszek; Mark Guttman; Alanna Sheinberg; Albie Law; Irita Karmalkar; Susan Perlman; Brian Clemente; Michael D. Geschwind; Sharon Sha; Joseph Winer; Gabriela Satris; Tom Warner; Maggie Burrows; Anne Rosser; Kathy Price; Sarah Hunt; Frederick Marshall; Amy Chesire; Mary Wodarski; Charlyne Hickey; Peter Panegyres; Joseph Lee; Maria Tedesco; Brenton Maxwell; Joel Perlmutter; Stacey Barton; Shineeka Smith; Zosia Miedzybrodzka; Daniela Rae; Vivien Vaughan; Mariella D'Alessandro; David Craufurd; Judith Bek; Elizabeth Howard; Pietro Mazzoni; Karen Marder; Paula Wasserman; Rajeev Kumar; Diane Erickson; Christina Reeves; Breanna Nickels; Vicki Wheelock; Lisa Kjer; Amanda Martin; Sarah Farias; Wayne Martin; Oksana Suchowersky; Pamela King; Marguerite Wieler; Satwinder Sran; Anwar Ahmed; Stephen Rao; Christine Reece; Alex Bura; Lyla Mourany; Phil Danzer; Kelsey Montross; Deborah Harrington; Holly Westervalt; Elizabeth Aylward; David J. Moser; Janet Williams; Nancy Downing; Vincent A. Magnotta; Hans J. Johnson; Thomas Brashers-Krug; Jatin Vaidya; Daniel O'Leary; Eun Young Kim; Spencer Lourens; Ying Zhang; Wenjing Lu; Cheryl Erwin; Martha Nance; H. Jeremy Bockholt; Jason Evans; Roland Zschiegner

doi:10.1080/13803395.2015.1101054

The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Janessa O. Carvalho, Jeffrey D. Long, Holly J. Westervelt, Megan M. Smith, Jared M. Bruce, Ji In Kim, James A. Mills, Jane S. Paulsen, Isabella De Soriano, Courtney Shadrick, Amanda Miller, Edmond Chiu, Joy Preston, Anita Goh, Stephanie Antonopoulos, Samantha Loi, Phyllis Chua, Angela Komiti, Lynn Raymond, Joji DecolongonMannie Fan, Allison Coleman, Christopher A. Ross, Mark Varvaris, Maryjane Ong, Nadine Yoritomo, William M. Mallonee, Greg Suter, Ali Samii, Emily P. Freney, Alma Macaraeg, Randi Jones, Cathy Wood-Siverio, Stewart A. Factor, Roger A. Barker, Sarah Mason, Natalie Valle Guzman, Elizabeth McCusker, Jane Griffith, Clement Loy, Jillian McMillan, David Gunn, Michael Orth, Sigurd Süßmuth, Katrin Barth, Sonja Trautmann, Daniela Schwenk, Carolin Eschenbach, Kimberly Quaid, Melissa Wesson, Joanne Wojcieszek, Mark Guttman, Alanna Sheinberg, Albie Law, Irita Karmalkar, Susan Perlman, Brian Clemente, Michael D. Geschwind, Sharon Sha, Joseph Winer, Gabriela Satris, Tom Warner, Maggie Burrows, Anne Rosser, Kathy Price, Sarah Hunt, Frederick Marshall, Amy Chesire, Mary Wodarski, Charlyne Hickey, Peter Panegyres, Joseph Lee, Maria Tedesco, Brenton Maxwell, Joel Perlmutter, Stacey Barton, Shineeka Smith, Zosia Miedzybrodzka, Daniela Rae, Vivien Vaughan, Mariella D'Alessandro, David Craufurd, Judith Bek, Elizabeth Howard, Pietro Mazzoni, Karen Marder, Paula Wasserman, Rajeev Kumar, Diane Erickson, Christina Reeves, Breanna Nickels, Vicki Wheelock, Lisa Kjer, Amanda Martin, Sarah Farias, Wayne Martin, Oksana Suchowersky, Pamela King, Marguerite Wieler, Satwinder Sran, Anwar Ahmed, Stephen Rao, Christine Reece, Alex Bura, Lyla Mourany, Phil Danzer, Kelsey Montross, Deborah Harrington, Holly Westervalt, Elizabeth Aylward, David J. Moser, Janet Williams, Nancy Downing, Vincent A. Magnotta, Hans J. Johnson, Thomas Brashers-Krug, Jatin Vaidya, Daniel O'Leary, Eun Young Kim, Spencer Lourens, Ying Zhang, Wenjing Lu, Cheryl Erwin, Martha Nance, H. Jeremy Bockholt, Jason Evans, Roland Zschiegner

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

Original language	English (US)
Pages (from-to)	217-226
Number of pages	10
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1080/13803395.2015.1101054
State	Published - Feb 7 2016

Keywords

Huntington disease
Neuropsychology
Oculomotor functioning
PREDICT-HD
Processing speed

ASJC Scopus subject areas

Clinical Neurology
Neuropsychology and Physiological Psychology
Neurology
Clinical Psychology

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Carvalho, J. O., Long, J. D., Westervelt, H. J., Smith, M. M., Bruce, J. M., Kim, J. I., Mills, J. A., Paulsen, J. S., De Soriano, I., Shadrick, C., Miller, A., Chiu, E., Preston, J., Goh, A., Antonopoulos, S., Loi, S., Chua, P., Komiti, A., Raymond, L., ... Zschiegner, R. (2016). The impact of oculomotor functioning on neuropsychological performance in Huntington disease. Journal of Clinical and Experimental Neuropsychology, 38(2), 217-226. https://doi.org/10.1080/13803395.2015.1101054

Carvalho, JO, Long, JD, Westervelt, HJ, Smith, MM, Bruce, JM, Kim, JI, Mills, JA, Paulsen, JS, De Soriano, I, Shadrick, C, Miller, A, Chiu, E, Preston, J, Goh, A, Antonopoulos, S, Loi, S, Chua, P, Komiti, A, Raymond, L, Decolongon, J, Fan, M, Coleman, A, Ross, CA, Varvaris, M, Ong, M, Yoritomo, N, Mallonee, WM, Suter, G, Samii, A, Freney, EP, Macaraeg, A, Jones, R, Wood-Siverio, C, Factor, SA, Barker, RA, Mason, S, Guzman, NV, McCusker, E, Griffith, J, Loy, C, McMillan, J, Gunn, D, Orth, M, Süßmuth, S, Barth, K, Trautmann, S, Schwenk, D, Eschenbach, C, Quaid, K, Wesson, M, Wojcieszek, J, Guttman, M, Sheinberg, A, Law, A, Karmalkar, I, Perlman, S, Clemente, B, Geschwind, MD, Sha, S, Winer, J, Satris, G, Warner, T, Burrows, M, Rosser, A, Price, K, Hunt, S, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Panegyres, P, Lee, J, Tedesco, M, Maxwell, B, Perlmutter, J, Barton, S, Smith, S, Miedzybrodzka, Z, Rae, D, Vaughan, V, D'Alessandro, M, Craufurd, D, Bek, J, Howard, E, Mazzoni, P, Marder, K, Wasserman, P, Kumar, R, Erickson, D, Reeves, C, Nickels, B, Wheelock, V, Kjer, L, Martin, A, Farias, S, Martin, W, Suchowersky, O, King, P, Wieler, M, Sran, S, Ahmed, A, Rao, S, Reece, C, Bura, A, Mourany, L, Danzer, P, Montross, K, Harrington, D, Westervalt, H, Aylward, E, Moser, DJ, Williams, J, Downing, N, Magnotta, VA, Johnson, HJ, Brashers-Krug, T, Vaidya, J, O'Leary, D, Young Kim, E, Lourens, S, Zhang, Y, Lu, W, Erwin, C, Nance, M, Bockholt, HJ, Evans, J & Zschiegner, R 2016, 'The impact of oculomotor functioning on neuropsychological performance in Huntington disease', Journal of Clinical and Experimental Neuropsychology, vol. 38, no. 2, pp. 217-226. https://doi.org/10.1080/13803395.2015.1101054

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title = "The impact of oculomotor functioning on neuropsychological performance in Huntington disease",

abstract = "Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.",

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AB - Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

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KW - Oculomotor functioning

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The impact of oculomotor functioning on neuropsychological performance in Huntington disease

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