The impact of oat (Avena sativa) consumption on biomarkers of renal function in patients with chronic kidney disease: A parallel randomized clinical trial

Mohammad Hossein Rouhani, Mojgan Mortazavi Najafabadi, Pamela J. Surkan, Ahmad Esmaillzadeh, Awat Feizi, Leila Azadbakht

Research output: Contribution to journalArticlepeer-review

Abstract

Background & objective: Animal studies report that oat (Avena sativa L) intake has favorable effects on kidney function. However, the effects of oat consumption have not been assessed in humans. The aim of this study was to examine the impact of oat intake on biomarkers of renal function in patients with chronic kidney disease (CKD). Methods: Fifty-two patients with CKD were randomly assigned to a control group (recommended to reduce intake of dietary protein, phosphorus, sodium and potassium) or an oat consumption group (given nutritional recommendations for controls +50 g/day oats). Blood urea nitrogen (BUN), serum creatinine (SCr), urine creatinine, serum albumin, serum potassium, parathyroid hormone (PTH), serum klotho and urine protein concentration were measured at baseline and after an eight-week intervention. Creatinine clearance was calculated using urine creatinine concentration. Results: Within group analysis showed a significant increase in BUN (P = 0.02) and serum potassium (P = 0.01) and a marginally significant increment in SCr (P = 0.08) among controls. However, changes in the oat group were not significant. In a multivariate adjusted model, we observed a significant difference in change of serum potassium (−0.03 mEq/L for oat group and 0.13 mEq/L for control group; P = 0.01) and a marginally significant difference in change of serum albumin (0.01 g/dl for oat group and −0.08 for control group; P = 0.08) between the two groups. There was no change in PTH concentration. Conclusion: Intake of oats may have a beneficial effect on serum albumin and serum potassium in patients with CKD. Registration code: Present study registered under IRCT.ir identifier no. IRCT2015050414551N2.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalClinical Nutrition
Volume37
Issue number1
DOIs
StatePublished - Feb 2018

Keywords

  • Avena sativa
  • Chronic kidney disease
  • Oats
  • Randomized clinical trial

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

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