The impact of mitotic errors on cell proliferation and tumorigenesis

Michelle S. Levine, Andrew J. Holland

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsiveness to immunotherapy. Finally, we survey the vulnerabilities exposed by cell division errors and how they can be exploited therapeutically.

Original languageEnglish (US)
Pages (from-to)620-638
Number of pages19
JournalGenes and Development
Volume32
Issue number9-10
DOIs
StatePublished - May 1 2018

Keywords

  • Aneuploidy
  • Chromosomal instability
  • Mitosis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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