The impact of luteal phase support on endometrial estrogen and progesterone receptor expression: A randomized control trial

Paul R. Brezina, Nikos F. Vlahos, Tsung Hsuan Lai, Jairo Garcia, Edward E Wallach, Yulian Zhao

Research output: Contribution to journalArticle

Abstract

Background: To assess the impact of luteal phase support on the expression of estrogen receptor (ER) alpha and progesterone receptors B (PR-B) on the endometrium of oocyte donors undergoing controlled ovarian hyperstimulation (COH).Methods: A prospective, randomized study was conducted in women undergoing controlled ovarian hyperstimulation for oocyte donation. Participants were randomized to receive no luteal support, vaginal progesterone alone, or vaginal progesterone plus orally administered 17 Beta estradiol. Endometrial biopsies were obtained at 4 time points in the luteal phase and evaluated by tissue microarray for expression of ER alpha and PR-B.Results: One-hundred and eight endometrial tissue samples were obtained from 12 patients. No differences were found in expression of ER alpha and PR-B among all the specimens with the exception of one sample value.Conclusions: The administration of progesterone during the luteal phase of COH for oocyte donor cycles, either with or without estrogen, does not significantly affect the endometrial expression of ER alpha and PR.

Original languageEnglish (US)
Article number16
JournalReproductive Biology and Endocrinology
Volume10
DOIs
StatePublished - Feb 24 2012

Fingerprint

Estrogen Receptor alpha
Luteal Phase
Progesterone Receptors
Estrogen Receptors
Progesterone
Oocytes
Oocyte Donation
Tissue Donors
Corpus Luteum
Endometrium
Estradiol
Estrogens
Prospective Studies
Biopsy
progesterone receptor B

Keywords

  • Controlled ovarian hyperstimulation
  • Endometrium
  • ER alpha
  • ERα

ASJC Scopus subject areas

  • Developmental Biology
  • Endocrinology
  • Reproductive Medicine
  • Medicine(all)

Cite this

The impact of luteal phase support on endometrial estrogen and progesterone receptor expression : A randomized control trial. / Brezina, Paul R.; Vlahos, Nikos F.; Lai, Tsung Hsuan; Garcia, Jairo; Wallach, Edward E; Zhao, Yulian.

In: Reproductive Biology and Endocrinology, Vol. 10, 16, 24.02.2012.

Research output: Contribution to journalArticle

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AU - Wallach, Edward E

AU - Zhao, Yulian

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