The impact of human immunodeficiency virus (HIV) co-infection on the economic burden of cutaneous leishmaniasis (CL) in Brazil and Potential Value of New CL drug treatments

Stephanie D. Kruchten, Kristina M. Bacon, Bruce Y. Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Convergence of geographic regions endemic for human immunodeficiency virus (HIV) and cutaneous leishmaniasis (CL) raise concerns that HIV co-infection may worsen CL burden, complicating already lengthy and costly CL treatments and highlighting a need for newer therapies. We constructed two Markov decision models to quantify impact of HIV on CL and help establish a target product profile for new CL treatments, accounting for co-infection. The HIV co-infection increased lifetime cost per CL case 11-371 times ($ 1, 349-45, 683) that of HIV-negative individuals ($ 123) and Brazil's CL burden from $ 1.6-16.0 million to $ 1.6-65.5 million. A new treatment could be a cost saving at ≤ $ 254 across several ranges (treatments seeking probabilities, side effect risks, cure rates) and continues to save costs up to $ 508 across treatment-seeking probabilities with a drug cure rate of ≥ 50%. The HIV co-infection can increase CL burden, suggesting more joint HIV and CL surveillance and control efforts are needed. Copyright

Original languageEnglish (US)
Pages (from-to)520-527
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume91
Issue number3
DOIs
StatePublished - Sep 1 2014

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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