The impact of group B Streptococcus prophylaxis on early onset neonatal infections

K. L. Ecker, Pamela Kimzey Donohue, Kwang Sik Kim, J. A. Shepard, Susan W Aucott

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To determine if changes have occurred in the causative pathogens and/or antibiotic susceptibility profiles in early onset neonatal infections since initiation of group B Streptococcus (GBS) prophylaxis and to determine risk factors for ampicillin/penicillin resistant microorganisms. STUDY DESIGN: Data on 220 infants with positive blood, urine, or cerebrospinal fluid cultures for bacteria or fungi at ≤seven days of age from 1990-2007 were examined and divided into three epochs, based on intrapartum antibiotic prophylactic (IAP) practices. Pathogens and antibiotic resistance were compared among epochs. RESULTS: A significant decrease in the incidence of GBS infections occurred over time, with no change in the incidence of other pathogens or the emergence of antibiotic resistance, including the very low-birthweight population. In regression analysis, ampicillin resistance was associated with male gender (OR 3.096). CONCLUSIONS: No emergence of antibiotic resistant pathogens was found following IAP use. Changing microorganisms and increasing antibiotic resistance found in prior studies are likely multifactorial. Further study is needed to continue to reduce the rates of common early onset pathogens.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalJournal of Neonatal-Perinatal Medicine
Volume6
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Streptococcus agalactiae
Microbial Drug Resistance
Anti-Bacterial Agents
Infection
Ampicillin Resistance
Incidence
Ampicillin
Penicillins
Cerebrospinal Fluid
Fungi
Regression Analysis
Urine
Bacteria
Population

Keywords

  • antibiotic resistance
  • early onset neonatal infections
  • Escherichia coli (E. coli)
  • Group B Streptococcus (GBS)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The impact of group B Streptococcus prophylaxis on early onset neonatal infections. / Ecker, K. L.; Donohue, Pamela Kimzey; Kim, Kwang Sik; Shepard, J. A.; Aucott, Susan W.

In: Journal of Neonatal-Perinatal Medicine, Vol. 6, No. 1, 2013, p. 37-44.

Research output: Contribution to journalArticle

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AU - Aucott, Susan W

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