The impact of functional constipation on quality of life of middleaged Black Americans: A prospective case-control study

Frank K. Friedenberg, Alia Dadabhai, Amiya Palit, Abhinav Sankineni

Research output: Contribution to journalReview article

Abstract

Purpose To quantify the impact of constipation on health-related quality of life (HRQoL) in Black Americans. Methods Case-control design. Black subjects referred for colon cancer screening with a Bristol Stool Score of 3-5 for >75% of bowel movements served as controls. Frequencymatched functional constipation subjects had to fulfill Rome III criteria. Both groups completed demographic and health surveys. Short Form-36 assessed HRQoL. Results We recruited 102 constipated patients and 100 controls. The groups were well matched demographically. After adjustment for comorbidities, SF-36 scores for vitality, bodily pain, social functioning, and role-emotional were significantly lower in constipated patients. Unadjusted physical and mental component summary scores (PCS and MCS) were significantly higher in the control group (47.1 ± 10.6 vs. 43.3 ± 8.6; P = 0.005 and 50.6 ± 12.4 vs. 43.4 ± 11.8; P < 0.001, respectively). After adjustment for comorbidities, PCS differences were no longer significant (P = 0.54); however, MCS differences were significant (P = 0.004). Marginal mean scores for the MCS for controls and constipated subjects were 49.9 ± 1.2 and 43.6 ± 1.2, respectively. The presence of a comorbidity was independently associated with PCS (P < 0.001) and MCS (P = 0.026) results. Conclusions Functional constipation has a significant impact on HRQoL in middle-aged Black Americans, particularly in regard to mental well-being.

Original languageEnglish (US)
Pages (from-to)1713-1717
Number of pages5
JournalQuality of Life Research
Volume21
Issue number10
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • Black American
  • Constipation
  • Quality of life
  • SF-36

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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