The impact of financial toxicity in gastrointestinal cancer patients

Christopher J. LaRocca, Arthur Li, Kelly Lafaro, Karen Clark, Matthew Loscalzo, Laleh G. Melstrom, Susanne G. Warner

Research output: Contribution to journalArticle

Abstract

Background: Biopsychosocial distress screening is a critical component of comprehensive cancer care. Financial issues are a common source of distress in this patient population. This study uses a biopsychosocial distress screening tool to determine the factors associated with financial toxicity and the impact of these stressors on gastrointestinal cancer patients. Methods: A 48-question, proprietary distress screening tool was administered to patients with gastrointestinal malignancies from 2009 to 2015. This validated, electronically-administered tool is given to all new patients. Responses were recorded on a 5-point Likert scale from 1 (not a problem) to 5 (very severe problem), with responses rated at ≥3 indicative of distress. Univariate and multivariate logistic regressions were used to analyze the data. Results: Most of the 1,027 patients had colorectal (50%) or hepatobiliary (31%) malignancies. Additionally, 34% of all patients expressed a high level of financial toxicity. Age greater than 65 (odds ratio: 0.63, 95% confidence interval: 0.47–0.86, P <.01), college education (odds ratio: 0.53, 95% confidence interval: 0.38–0.73, P <.0001), being partnered (odds ratio: 0.61, 95% confidence interval: 0.44–0.84, P <.01), and annual income greater than $40,000 (odds ratio: 0.27, 95% confidence interval: 0.19–0.38, P <.0001) were all protective against financial toxicity on univariate analysis. Also, heavy tobacco use was associated significantly with increased distress on univariate analysis (odds ratio: 2.79, 95% confidence interval: 1.38–5.78, P <.01). With the exception of partnered status (odds ratio: 1.18, 95% confidence interval: 0.76–1.85, P =.46), all these variables retained their significant association with financial toxicity in the multivariate model. Conclusion: Financial toxicity impacts a large number of cancer patients. Further study of at-risk populations may identify patients who would benefit from pre-emptive education and counseling interventions as part of their routine cancer care.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalSurgery (United States)
Volume168
Issue number1
DOIs
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Surgery

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    LaRocca, C. J., Li, A., Lafaro, K., Clark, K., Loscalzo, M., Melstrom, L. G., & Warner, S. G. (2020). The impact of financial toxicity in gastrointestinal cancer patients. Surgery (United States), 168(1), 167-172. https://doi.org/10.1016/j.surg.2020.02.006