The Impact of Financial Conflicts of Interest in Plastic Surgery

Are They All Created Equal?

Joseph Lopez, Ilona Juan, Adela Wu, Georges Samaha, Brian Cho, J. D. Luck, Ashwin Soni, Jacqueline Milton, James W. May, Anthony P. Tufaro, Amir Dorafshar

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Recently, several studies have demonstrated that articles that disclose conflicts of interests (COI) are associated with publication of positive results. The purpose of this study was to learn more about the different types of COI as they relate to the general topic of COI in plastic surgery. Specifically, we aimed to examine whether different types of COI are more likely than others to be associated with the presentation of positive findings. METHODS: We reviewed all original articles in Annals of Plastic Surgery, Journal of Plastic, Reconstructive, and Aesthetic Surgery, and Plastic & Reconstructive Surgery from January 1, 2012, to December 31, 2013. All scientific articles were analyzed, and several article characteristics were extracted. Disclosed COI were categorized into the following categories: consultant/employee, royalties/stock options, and research support. The findings reported in each article abstract were blindly graded as reporting a positive, negative, neutral, or not applicable result. A multivariable analysis was performed to determine whether an association existed between certain types of COI and publication of positive conclusions. RESULTS: A total of 3124 articles were identified of which 1185 fulfilled the inclusion criteria. Financial COI were reported in 153 studies (12.9%). The most common type of COI was “research support” (7.3%), whereas the least common was “royalties/stock options” (1.2%). Rates of different types of COI varied significantly by plastic surgery subspecialty field (P <0.001). In the multivariable analysis, authors who disclosed COI related to research support, consultant/employee, and royalties/stock options were 1.31, 6.62, and 8.72 times more likely, respectively, to publish positive findings when compared with authors that disclosed no COI after correcting for potential confounding factors. However, consultancy/employee status was the only COI category statistically associated with publication of positive results (P <0.001). CONCLUSIONS: Self-reported COI are uncommon in plastic surgery research. Our results provide evidence that certain types of financial COI are more likely than others to be associated with the presentation of positive findings. This analysis suggests that certain investigators may be more biased, consciously or unconsciously, by the type of financial benefit offered by industry.

Original languageEnglish (US)
JournalAnnals of Plastic Surgery
DOIs
StateAccepted/In press - May 23 2016

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Conflict of Interest
Plastic Surgery
Reconstructive Surgical Procedures
Publications
Consultants
Plastics

ASJC Scopus subject areas

  • Surgery

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The Impact of Financial Conflicts of Interest in Plastic Surgery : Are They All Created Equal? / Lopez, Joseph; Juan, Ilona; Wu, Adela; Samaha, Georges; Cho, Brian; Luck, J. D.; Soni, Ashwin; Milton, Jacqueline; May, James W.; Tufaro, Anthony P.; Dorafshar, Amir.

In: Annals of Plastic Surgery, 23.05.2016.

Research output: Contribution to journalArticle

Lopez, J, Juan, I, Wu, A, Samaha, G, Cho, B, Luck, JD, Soni, A, Milton, J, May, JW, Tufaro, AP & Dorafshar, A 2016, 'The Impact of Financial Conflicts of Interest in Plastic Surgery: Are They All Created Equal?', Annals of Plastic Surgery. https://doi.org/10.1097/SAP.0000000000000834
Lopez, Joseph ; Juan, Ilona ; Wu, Adela ; Samaha, Georges ; Cho, Brian ; Luck, J. D. ; Soni, Ashwin ; Milton, Jacqueline ; May, James W. ; Tufaro, Anthony P. ; Dorafshar, Amir. / The Impact of Financial Conflicts of Interest in Plastic Surgery : Are They All Created Equal?. In: Annals of Plastic Surgery. 2016.
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abstract = "BACKGROUND: Recently, several studies have demonstrated that articles that disclose conflicts of interests (COI) are associated with publication of positive results. The purpose of this study was to learn more about the different types of COI as they relate to the general topic of COI in plastic surgery. Specifically, we aimed to examine whether different types of COI are more likely than others to be associated with the presentation of positive findings. METHODS: We reviewed all original articles in Annals of Plastic Surgery, Journal of Plastic, Reconstructive, and Aesthetic Surgery, and Plastic & Reconstructive Surgery from January 1, 2012, to December 31, 2013. All scientific articles were analyzed, and several article characteristics were extracted. Disclosed COI were categorized into the following categories: consultant/employee, royalties/stock options, and research support. The findings reported in each article abstract were blindly graded as reporting a positive, negative, neutral, or not applicable result. A multivariable analysis was performed to determine whether an association existed between certain types of COI and publication of positive conclusions. RESULTS: A total of 3124 articles were identified of which 1185 fulfilled the inclusion criteria. Financial COI were reported in 153 studies (12.9{\%}). The most common type of COI was “research support” (7.3{\%}), whereas the least common was “royalties/stock options” (1.2{\%}). Rates of different types of COI varied significantly by plastic surgery subspecialty field (P <0.001). In the multivariable analysis, authors who disclosed COI related to research support, consultant/employee, and royalties/stock options were 1.31, 6.62, and 8.72 times more likely, respectively, to publish positive findings when compared with authors that disclosed no COI after correcting for potential confounding factors. However, consultancy/employee status was the only COI category statistically associated with publication of positive results (P <0.001). CONCLUSIONS: Self-reported COI are uncommon in plastic surgery research. Our results provide evidence that certain types of financial COI are more likely than others to be associated with the presentation of positive findings. This analysis suggests that certain investigators may be more biased, consciously or unconsciously, by the type of financial benefit offered by industry.",
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AU - Lopez, Joseph

AU - Juan, Ilona

AU - Wu, Adela

AU - Samaha, Georges

AU - Cho, Brian

AU - Luck, J. D.

AU - Soni, Ashwin

AU - Milton, Jacqueline

AU - May, James W.

AU - Tufaro, Anthony P.

AU - Dorafshar, Amir

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N2 - BACKGROUND: Recently, several studies have demonstrated that articles that disclose conflicts of interests (COI) are associated with publication of positive results. The purpose of this study was to learn more about the different types of COI as they relate to the general topic of COI in plastic surgery. Specifically, we aimed to examine whether different types of COI are more likely than others to be associated with the presentation of positive findings. METHODS: We reviewed all original articles in Annals of Plastic Surgery, Journal of Plastic, Reconstructive, and Aesthetic Surgery, and Plastic & Reconstructive Surgery from January 1, 2012, to December 31, 2013. All scientific articles were analyzed, and several article characteristics were extracted. Disclosed COI were categorized into the following categories: consultant/employee, royalties/stock options, and research support. The findings reported in each article abstract were blindly graded as reporting a positive, negative, neutral, or not applicable result. A multivariable analysis was performed to determine whether an association existed between certain types of COI and publication of positive conclusions. RESULTS: A total of 3124 articles were identified of which 1185 fulfilled the inclusion criteria. Financial COI were reported in 153 studies (12.9%). The most common type of COI was “research support” (7.3%), whereas the least common was “royalties/stock options” (1.2%). Rates of different types of COI varied significantly by plastic surgery subspecialty field (P <0.001). In the multivariable analysis, authors who disclosed COI related to research support, consultant/employee, and royalties/stock options were 1.31, 6.62, and 8.72 times more likely, respectively, to publish positive findings when compared with authors that disclosed no COI after correcting for potential confounding factors. However, consultancy/employee status was the only COI category statistically associated with publication of positive results (P <0.001). CONCLUSIONS: Self-reported COI are uncommon in plastic surgery research. Our results provide evidence that certain types of financial COI are more likely than others to be associated with the presentation of positive findings. This analysis suggests that certain investigators may be more biased, consciously or unconsciously, by the type of financial benefit offered by industry.

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