The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis

H. M. Walters, N. Pan, T. J A Lehman, A. Adams, G. D. Kalliolias, Y. S. Zhu, F. Santiago, J. Nguyen, L. Sitaras, S. Cunningham-Rundles, T. J. Walsh, S. S. Toussi

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin (IL)-1β, IL-6, IL-8, IL-10 and IL-17 were measured at baseline for JIA subjects and healthy controls (HCs). Cytokine levels were then measured at four time-points after initiation of TNF-α inhibition for anti-TNF-α-treated (anti-TNF) JIA subjects, and at two subsequent time-points for other JIA (non-TNF) subjects. JIA disease activity by Childhood Health Assessment Questionnaire (CHAQ) disability index/pain score and physician joint count/global assessment was recorded. Sixteen anti-TNF, 31 non-TNF and 16 HCs were analysed. Among JIA subjects, those with higher baseline disease activity (subsequent anti-TNFs) had higher baseline TNF-α, IL-6 and IL-8 than those with lower disease activity (non-TNFs) (P

Original languageEnglish (US)
Pages (from-to)308-317
Number of pages10
JournalClinical and Experimental Immunology
Volume184
Issue number3
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Juvenile Arthritis
Tumor Necrosis Factor-alpha
Cytokines
Therapeutics
Interleukin-8
Interleukin-6
Necrosis
Interleukin-17
Interleukin-1
Interleukin-10
Healthy Volunteers
Joints
Physicians
Pain
Health

Keywords

  • Arthritis
  • Autoimmunity
  • Cytokines

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis. / Walters, H. M.; Pan, N.; Lehman, T. J A; Adams, A.; Kalliolias, G. D.; Zhu, Y. S.; Santiago, F.; Nguyen, J.; Sitaras, L.; Cunningham-Rundles, S.; Walsh, T. J.; Toussi, S. S.

In: Clinical and Experimental Immunology, Vol. 184, No. 3, 01.06.2016, p. 308-317.

Research output: Contribution to journalArticle

Walters, HM, Pan, N, Lehman, TJA, Adams, A, Kalliolias, GD, Zhu, YS, Santiago, F, Nguyen, J, Sitaras, L, Cunningham-Rundles, S, Walsh, TJ & Toussi, SS 2016, 'The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis', Clinical and Experimental Immunology, vol. 184, no. 3, pp. 308-317. https://doi.org/10.1111/cei.12782
Walters, H. M. ; Pan, N. ; Lehman, T. J A ; Adams, A. ; Kalliolias, G. D. ; Zhu, Y. S. ; Santiago, F. ; Nguyen, J. ; Sitaras, L. ; Cunningham-Rundles, S. ; Walsh, T. J. ; Toussi, S. S. / The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis. In: Clinical and Experimental Immunology. 2016 ; Vol. 184, No. 3. pp. 308-317.
@article{c22e41b77c1a4cac9eaad35957b5f5e8,
title = "The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis",
abstract = "The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin (IL)-1β, IL-6, IL-8, IL-10 and IL-17 were measured at baseline for JIA subjects and healthy controls (HCs). Cytokine levels were then measured at four time-points after initiation of TNF-α inhibition for anti-TNF-α-treated (anti-TNF) JIA subjects, and at two subsequent time-points for other JIA (non-TNF) subjects. JIA disease activity by Childhood Health Assessment Questionnaire (CHAQ) disability index/pain score and physician joint count/global assessment was recorded. Sixteen anti-TNF, 31 non-TNF and 16 HCs were analysed. Among JIA subjects, those with higher baseline disease activity (subsequent anti-TNFs) had higher baseline TNF-α, IL-6 and IL-8 than those with lower disease activity (non-TNFs) (P",
keywords = "Arthritis, Autoimmunity, Cytokines",
author = "Walters, {H. M.} and N. Pan and Lehman, {T. J A} and A. Adams and Kalliolias, {G. D.} and Zhu, {Y. S.} and F. Santiago and J. Nguyen and L. Sitaras and S. Cunningham-Rundles and Walsh, {T. J.} and Toussi, {S. S.}",
year = "2016",
month = "6",
day = "1",
doi = "10.1111/cei.12782",
language = "English (US)",
volume = "184",
pages = "308--317",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis

AU - Walters, H. M.

AU - Pan, N.

AU - Lehman, T. J A

AU - Adams, A.

AU - Kalliolias, G. D.

AU - Zhu, Y. S.

AU - Santiago, F.

AU - Nguyen, J.

AU - Sitaras, L.

AU - Cunningham-Rundles, S.

AU - Walsh, T. J.

AU - Toussi, S. S.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin (IL)-1β, IL-6, IL-8, IL-10 and IL-17 were measured at baseline for JIA subjects and healthy controls (HCs). Cytokine levels were then measured at four time-points after initiation of TNF-α inhibition for anti-TNF-α-treated (anti-TNF) JIA subjects, and at two subsequent time-points for other JIA (non-TNF) subjects. JIA disease activity by Childhood Health Assessment Questionnaire (CHAQ) disability index/pain score and physician joint count/global assessment was recorded. Sixteen anti-TNF, 31 non-TNF and 16 HCs were analysed. Among JIA subjects, those with higher baseline disease activity (subsequent anti-TNFs) had higher baseline TNF-α, IL-6 and IL-8 than those with lower disease activity (non-TNFs) (P

AB - The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin (IL)-1β, IL-6, IL-8, IL-10 and IL-17 were measured at baseline for JIA subjects and healthy controls (HCs). Cytokine levels were then measured at four time-points after initiation of TNF-α inhibition for anti-TNF-α-treated (anti-TNF) JIA subjects, and at two subsequent time-points for other JIA (non-TNF) subjects. JIA disease activity by Childhood Health Assessment Questionnaire (CHAQ) disability index/pain score and physician joint count/global assessment was recorded. Sixteen anti-TNF, 31 non-TNF and 16 HCs were analysed. Among JIA subjects, those with higher baseline disease activity (subsequent anti-TNFs) had higher baseline TNF-α, IL-6 and IL-8 than those with lower disease activity (non-TNFs) (P

KW - Arthritis

KW - Autoimmunity

KW - Cytokines

UR - http://www.scopus.com/inward/record.url?scp=84963680048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963680048&partnerID=8YFLogxK

U2 - 10.1111/cei.12782

DO - 10.1111/cei.12782

M3 - Article

VL - 184

SP - 308

EP - 317

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -