The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing

Traci A. Wilgus, Valerie K. Bergdall, Kathleen L. Tober, Kara J. Hill, Srabani Mitra, Nicholas A. Flavahan, Tatiana M. Oberyszyn

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclooxygenase-2 (COX-2) and the prostaglandin products generated as a result of COX-2 activity mediate a variety of biological and pathological pro-cesses. Scarless healing occurs in fetal skin in the first and second trimesters of development. This scarless healing process is known to proceed without a significant Inflammatory response, which appears to be important for the lack of scarring. Because the COX-2 pathway is an integral component of inflammation, we investigated its role in the fetal repair process using a mouse model of scarless fetal wound healing. COX-2 expression in scarless and fibrotic fetal wounds was examined. In addition, the ability of exogenous prostaglandin E2 to alter scarless fetal healing was evaluated. The results suggest that the COX-2 pathway is involved in scar production hi fetal skin and that targeting COX-2 may be useful for limiting scar formation hi adult skin.

Original languageEnglish (US)
Pages (from-to)753-761
Number of pages9
JournalAmerican Journal of Pathology
Volume165
Issue number3
DOIs
StatePublished - Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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