TY - JOUR
T1 - The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing
AU - Wilgus, Traci A.
AU - Bergdall, Valerie K.
AU - Tober, Kathleen L.
AU - Hill, Kara J.
AU - Mitra, Srabani
AU - Flavahan, Nicholas A.
AU - Oberyszyn, Tatiana M.
PY - 2004/9
Y1 - 2004/9
N2 - Cyclooxygenase-2 (COX-2) and the prostaglandin products generated as a result of COX-2 activity mediate a variety of biological and pathological pro-cesses. Scarless healing occurs in fetal skin in the first and second trimesters of development. This scarless healing process is known to proceed without a significant Inflammatory response, which appears to be important for the lack of scarring. Because the COX-2 pathway is an integral component of inflammation, we investigated its role in the fetal repair process using a mouse model of scarless fetal wound healing. COX-2 expression in scarless and fibrotic fetal wounds was examined. In addition, the ability of exogenous prostaglandin E2 to alter scarless fetal healing was evaluated. The results suggest that the COX-2 pathway is involved in scar production hi fetal skin and that targeting COX-2 may be useful for limiting scar formation hi adult skin.
AB - Cyclooxygenase-2 (COX-2) and the prostaglandin products generated as a result of COX-2 activity mediate a variety of biological and pathological pro-cesses. Scarless healing occurs in fetal skin in the first and second trimesters of development. This scarless healing process is known to proceed without a significant Inflammatory response, which appears to be important for the lack of scarring. Because the COX-2 pathway is an integral component of inflammation, we investigated its role in the fetal repair process using a mouse model of scarless fetal wound healing. COX-2 expression in scarless and fibrotic fetal wounds was examined. In addition, the ability of exogenous prostaglandin E2 to alter scarless fetal healing was evaluated. The results suggest that the COX-2 pathway is involved in scar production hi fetal skin and that targeting COX-2 may be useful for limiting scar formation hi adult skin.
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U2 - 10.1016/S0002-9440(10)63338-X
DO - 10.1016/S0002-9440(10)63338-X
M3 - Article
C2 - 15331400
AN - SCOPUS:4344643930
SN - 0002-9440
VL - 165
SP - 753
EP - 761
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 3
ER -