The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial

Janelle W. Coughlin; Phillip J. Brantley; Catherine M. Champagne; William M. Vollmer; Victor J. Stevens; Kristine Funk; Arlene T. Dalcin; Gerald J. Jerome; Valerie H. Myers; Crystal Tyson; Bryan C. Batch; Jeanne Charleston; Catherine M. Loria; Alan Bauck; Jack F. Hollis; Laura P. Svetkey; Lawrence J. Appel

doi:10.1002/oby.21454

The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial

Janelle W. Coughlin, Phillip J. Brantley, Catherine M. Champagne, William M. Vollmer, Victor J. Stevens, Kristine Funk, Arlene T. Dalcin, Gerald J. Jerome, Valerie H. Myers, Crystal Tyson, Bryan C. Batch, Jeanne Charleston, Catherine M. Loria, Alan Bauck, Jack F. Hollis, Laura P. Svetkey, Lawrence J. Appel

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective In the Weight Loss Maintenance (WLM) Trial, a personal contact (PC) intervention sustained greater weight loss relative to a self-directed (SD) group over 30 months. This study investigated the effects of continued intervention over an additional 30 months and overall weight change across the entire WLM Trial. Methods WLM had 3 phases. Phase 1 was a 6-month weight loss program. In Phase 2, those who lost ≥4 kg were randomized to a 30-month maintenance trial. In Phase 3, PC participants (n = 196, three sites) were re-randomized to no further intervention (PC-Control) or continued intervention (PC-Active) for 30 more months; 218 SD participants were also followed. Results During Phase 3, weight increased 1.0 kg in PC-Active and 0.5 kg in PC-Control (mean difference 0.6 kg; 95% CI:-1.4 to 2.7; P = 0.54). Mean weight change over the entire study was -3.2 kg in those originally assigned to PC (PC-Combined) and -1.6 kg in SD (mean difference -1.6 kg; 95% CI:-3.0 to -0.1; P = 0.04). Conclusions After 30 months of the PC maintenance intervention, continuation for another 30 months provided no additional benefit. However, across the entire study, weight loss was slightly greater in those originally assigned to PC.

Original language	English (US)
Pages (from-to)	1046-1053
Number of pages	8
Journal	Obesity
Volume	24
Issue number	5
DOIs	https://doi.org/10.1002/oby.21454
State	Published - May 1 2016

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1002/oby.21454

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Coughlin, J. W., Brantley, P. J., Champagne, C. M., Vollmer, W. M., Stevens, V. J., Funk, K., Dalcin, A. T., Jerome, G. J., Myers, V. H., Tyson, C., Batch, B. C., Charleston, J., Loria, C. M., Bauck, A., Hollis, J. F., Svetkey, L. P., & Appel, L. J. (2016). The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial. Obesity, 24(5), 1046-1053. https://doi.org/10.1002/oby.21454

Coughlin, JW, Brantley, PJ, Champagne, CM, Vollmer, WM, Stevens, VJ, Funk, K, Dalcin, AT, Jerome, GJ, Myers, VH, Tyson, C, Batch, BC, Charleston, J, Loria, CM, Bauck, A, Hollis, JF, Svetkey, LP & Appel, LJ 2016, 'The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial', Obesity, vol. 24, no. 5, pp. 1046-1053. https://doi.org/10.1002/oby.21454

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title = "The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial",

abstract = "Objective In the Weight Loss Maintenance (WLM) Trial, a personal contact (PC) intervention sustained greater weight loss relative to a self-directed (SD) group over 30 months. This study investigated the effects of continued intervention over an additional 30 months and overall weight change across the entire WLM Trial. Methods WLM had 3 phases. Phase 1 was a 6-month weight loss program. In Phase 2, those who lost ≥4 kg were randomized to a 30-month maintenance trial. In Phase 3, PC participants (n = 196, three sites) were re-randomized to no further intervention (PC-Control) or continued intervention (PC-Active) for 30 more months; 218 SD participants were also followed. Results During Phase 3, weight increased 1.0 kg in PC-Active and 0.5 kg in PC-Control (mean difference 0.6 kg; 95% CI:-1.4 to 2.7; P = 0.54). Mean weight change over the entire study was -3.2 kg in those originally assigned to PC (PC-Combined) and -1.6 kg in SD (mean difference -1.6 kg; 95% CI:-3.0 to -0.1; P = 0.04). Conclusions After 30 months of the PC maintenance intervention, continuation for another 30 months provided no additional benefit. However, across the entire study, weight loss was slightly greater in those originally assigned to PC.",

author = "Coughlin, {Janelle W.} and Brantley, {Phillip J.} and Champagne, {Catherine M.} and Vollmer, {William M.} and Stevens, {Victor J.} and Kristine Funk and Dalcin, {Arlene T.} and Jerome, {Gerald J.} and Myers, {Valerie H.} and Crystal Tyson and Batch, {Bryan C.} and Jeanne Charleston and Loria, {Catherine M.} and Alan Bauck and Hollis, {Jack F.} and Svetkey, {Laura P.} and Appel, {Lawrence J.}",

note = "Publisher Copyright: {\textcopyright} 2016 The Obesity Society.",

year = "2016",

month = may,

day = "1",

doi = "10.1002/oby.21454",

language = "English (US)",

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T2 - Five-year results from the weight loss maintenance trial

AU - Coughlin, Janelle W.

AU - Brantley, Phillip J.

AU - Champagne, Catherine M.

AU - Vollmer, William M.

AU - Stevens, Victor J.

AU - Funk, Kristine

AU - Dalcin, Arlene T.

AU - Jerome, Gerald J.

AU - Myers, Valerie H.

AU - Tyson, Crystal

AU - Batch, Bryan C.

AU - Charleston, Jeanne

AU - Loria, Catherine M.

AU - Bauck, Alan

AU - Hollis, Jack F.

AU - Svetkey, Laura P.

AU - Appel, Lawrence J.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Objective In the Weight Loss Maintenance (WLM) Trial, a personal contact (PC) intervention sustained greater weight loss relative to a self-directed (SD) group over 30 months. This study investigated the effects of continued intervention over an additional 30 months and overall weight change across the entire WLM Trial. Methods WLM had 3 phases. Phase 1 was a 6-month weight loss program. In Phase 2, those who lost ≥4 kg were randomized to a 30-month maintenance trial. In Phase 3, PC participants (n = 196, three sites) were re-randomized to no further intervention (PC-Control) or continued intervention (PC-Active) for 30 more months; 218 SD participants were also followed. Results During Phase 3, weight increased 1.0 kg in PC-Active and 0.5 kg in PC-Control (mean difference 0.6 kg; 95% CI:-1.4 to 2.7; P = 0.54). Mean weight change over the entire study was -3.2 kg in those originally assigned to PC (PC-Combined) and -1.6 kg in SD (mean difference -1.6 kg; 95% CI:-3.0 to -0.1; P = 0.04). Conclusions After 30 months of the PC maintenance intervention, continuation for another 30 months provided no additional benefit. However, across the entire study, weight loss was slightly greater in those originally assigned to PC.

AB - Objective In the Weight Loss Maintenance (WLM) Trial, a personal contact (PC) intervention sustained greater weight loss relative to a self-directed (SD) group over 30 months. This study investigated the effects of continued intervention over an additional 30 months and overall weight change across the entire WLM Trial. Methods WLM had 3 phases. Phase 1 was a 6-month weight loss program. In Phase 2, those who lost ≥4 kg were randomized to a 30-month maintenance trial. In Phase 3, PC participants (n = 196, three sites) were re-randomized to no further intervention (PC-Control) or continued intervention (PC-Active) for 30 more months; 218 SD participants were also followed. Results During Phase 3, weight increased 1.0 kg in PC-Active and 0.5 kg in PC-Control (mean difference 0.6 kg; 95% CI:-1.4 to 2.7; P = 0.54). Mean weight change over the entire study was -3.2 kg in those originally assigned to PC (PC-Combined) and -1.6 kg in SD (mean difference -1.6 kg; 95% CI:-3.0 to -0.1; P = 0.04). Conclusions After 30 months of the PC maintenance intervention, continuation for another 30 months provided no additional benefit. However, across the entire study, weight loss was slightly greater in those originally assigned to PC.

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The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial

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