The impact of androgen actions in neurons on metabolic health and disease

Jamie J. Morford, Sheng Wu, Franck Mauvais-Jarvis

Research output: Contribution to journalArticle

Abstract

The male hormone testosterone exerts different effects on glucose and energy homeostasis in males and females. Testosterone deficiency predisposes males to visceral obesity, insulin resistance and type 2 diabetes. However, testosterone excess predisposes females to similar metabolic dysfunction. Here, we review the effects of testosterone actions in the central nervous system on metabolic function in males and females. In particular, we highlight changes within the hypothalamus that control glucose and energy homeostasis. We distinguish the organizational effects of testosterone in the programming of neural circuitry during development from the activational effects of testosterone during adulthood. Finally, we explore potential sites where androgen might be acting to impact metabolism within the central nervous system.

Original languageEnglish (US)
JournalMolecular and Cellular Endocrinology
DOIs
StateAccepted/In press - 2017

Keywords

  • Androgen receptor (AR)
  • Arcuate nucleus (ARC)
  • Central nervous system (CNS)
  • Hypothalamus
  • Insulin resistance
  • Metabolism
  • Obesity
  • Polycystic ovarian syndrome (PCOS)
  • Sex differences
  • Testosterone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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