The impact of a reformulation of extended-release oxycodone designed to deter abuse in a sample of prescription opioid abusers

Jennifer R. Havens, Carl G. Leukefeld, Angela M. DeVeaugh-Geiss, Paul Coplan, Howard D. Chilcoat

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Prescription opioid abuse is a significant public health concern that requires strategies to reduce its impact, including development of abuse deterrent formulations. OxyContin®, an extended-release oxycodone (ERO) formulation, has been widely abused. This study assessed the effects of reformulated ERO, designed to be more difficult to manipulate for purposes of intranasal and intravenous abuse, on patterns of opioid abuse among a sample of individuals from rural Appalachia with a history of ERO abuse. Methods: Structured interviews assessing opioid abuse (past 30-day abuse and retrospectively reported abuse prior to the reformulation in August 2010) were completed by 189 individuals between December 2010 and September 2011. Results: The past 30-day prevalence and frequency of reformulated ERO abuse through any route (33%, 1.9 days/month), snorting (5%, 0.2 days/month), and injecting (0.5%,

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalDrug and Alcohol Dependence
Volume139
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Abuse deterrent formulation
  • ER oxycodone
  • Extended-release oxycodone
  • Prescription opioid abuse
  • Tamper resistant formulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Toxicology
  • Pharmacology
  • Pharmacology (medical)
  • Medicine(all)

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