The immunology of tuberculous pleurisy

Jerrold J. Ellner, Peter F. Barnes, Robert S. Wallis, Robert L. Modlin

Research output: Contribution to journalArticle

Abstract

Tuberculous pleurisy results when a subpleural nodule discharges mycobacterial antigens into the pleural space of a hypersensitive host. The clinical syndrome is a reflection of an in situ delayed-type hypersensitivity reaction in which plasma proteins are exuded into the pleural space and T-helper cells accumulate, proliferate, and produce, and release inflammatory mediators. The immune response initially contains the local infection, but in the absence of therapy, the host is at great risk of developing tuberculosis during the next 5 years. The focal accumulation of vigorously responsive T-helper cells and activated B cells in the pleural space may prove useful in identifying mycobacterial constituents which are immunogenic and possibly candidate vaccine antigens.

Original languageEnglish (US)
Pages (from-to)335-342
Number of pages8
JournalSeminars in Respiratory Infections
Volume3
Issue number4
StatePublished - Dec 1988
Externally publishedYes

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Pleural Tuberculosis
Helper-Inducer T-Lymphocytes
Allergy and Immunology
Antigens
Delayed Hypersensitivity
Blood Proteins
Tuberculosis
B-Lymphocytes
Vaccines
Infection
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Microbiology (medical)

Cite this

Ellner, J. J., Barnes, P. F., Wallis, R. S., & Modlin, R. L. (1988). The immunology of tuberculous pleurisy. Seminars in Respiratory Infections, 3(4), 335-342.

The immunology of tuberculous pleurisy. / Ellner, Jerrold J.; Barnes, Peter F.; Wallis, Robert S.; Modlin, Robert L.

In: Seminars in Respiratory Infections, Vol. 3, No. 4, 12.1988, p. 335-342.

Research output: Contribution to journalArticle

Ellner, JJ, Barnes, PF, Wallis, RS & Modlin, RL 1988, 'The immunology of tuberculous pleurisy', Seminars in Respiratory Infections, vol. 3, no. 4, pp. 335-342.
Ellner JJ, Barnes PF, Wallis RS, Modlin RL. The immunology of tuberculous pleurisy. Seminars in Respiratory Infections. 1988 Dec;3(4):335-342.
Ellner, Jerrold J. ; Barnes, Peter F. ; Wallis, Robert S. ; Modlin, Robert L. / The immunology of tuberculous pleurisy. In: Seminars in Respiratory Infections. 1988 ; Vol. 3, No. 4. pp. 335-342.
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