The immunoglobulin E receptor: Expression and regulation

Edward R. Conner, Sarbjit S. Saini

Research output: Contribution to journalReview article

Abstract

The interaction of immunoglobulin E (IgE) and its receptors is critical for the manifestation of allergic disease. Currently, IgE receptors include the high-affinity FcεRI and the low-affinity FcεRII. FcεRI is a tetrameric or trimeric complex, and each has distinct expression patterns and unique functional consequences. In general, serum levels of IgE regulate FcεRI expression, and novel therapies that lower the concentration of IgE have provided insights into the contribution of this receptor in allergic disease. Newer therapies targeting FcεRI-signaling elements and the low-affinity IgE receptor, FcεRII (CD23), are being developed.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalCurrent allergy and asthma reports
Volume5
Issue number3
DOIs
StatePublished - May 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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