The interaction of immunoglobulin E (IgE) and its receptors is critical for the manifestation of allergic disease. Currently, IgE receptors include the high-affinity FcεRI and the low-affinity FcεRII. FcεRI is a tetrameric or trimeric complex, and each has distinct expression patterns and unique functional consequences. In general, serum levels of IgE regulate FcεRI expression, and novel therapies that lower the concentration of IgE have provided insights into the contribution of this receptor in allergic disease. Newer therapies targeting FcεRI-signaling elements and the low-affinity IgE receptor, FcεRII (CD23), are being developed.
ASJC Scopus subject areas
- Immunology and Allergy
- Pulmonary and Respiratory Medicine