The immunoglobulin constant region contributes to affinity and specificity

Marcela Torres, Arturo Casadevall

Research output: Contribution to journalReview article

Abstract

A central dogma in immunology is that antibody specificity is solely the result of variable (V)-region interactions with an antigen. However, this view is not tenable in light of numerous reports that constant heavy (CH) domains can affect binding affinity and specificity and V-region structure. Kinetic and thermodynamic proof for the occurrence of this phenomenon is now available. CH-region effects on affinity and specificity suggest new mechanisms for generating antibody diversity and polyreactivity (multispecificity) that impact current views on idiotype regulation, autoimmunity, and B cell selection and change our understanding of vaccine responses.

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalTrends in Immunology
Volume29
Issue number2
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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