TY - JOUR
T1 - The immune system and neuropsychiatric diseases
AU - Kerr, Douglas
AU - Krishnan, Chitra
AU - Pucak, Michele L.
AU - Carmen, Jessica
PY - 2005/12
Y1 - 2005/12
N2 - The immune system has a complex and dynamic relationship with the nervous system, both in health and disease. The immune system surveys the central and peripheral nervous systems, becoming activated in response to foreign substances, infectious particles or neoplasms. Conversely, the nervous system modulates immune system function both through the neuroendocrine axis and through vagus nerve efferents. In disease states, this dynamic relationship is perturbed, resulting in neuropsychiatric diseases. In this manuscript, we will summarize fundamental principles of the immune system and its interaction with the nervous system. We will describe the critical components of the adaptive and innate branches of the immune system and will describe important effectors and signalling pathways in each. By understanding the principles of the immune system and how these principles relate to nervous system function, the reader will be prepared to interpret subsequent manscripts in this issue.
AB - The immune system has a complex and dynamic relationship with the nervous system, both in health and disease. The immune system surveys the central and peripheral nervous systems, becoming activated in response to foreign substances, infectious particles or neoplasms. Conversely, the nervous system modulates immune system function both through the neuroendocrine axis and through vagus nerve efferents. In disease states, this dynamic relationship is perturbed, resulting in neuropsychiatric diseases. In this manuscript, we will summarize fundamental principles of the immune system and its interaction with the nervous system. We will describe the critical components of the adaptive and innate branches of the immune system and will describe important effectors and signalling pathways in each. By understanding the principles of the immune system and how these principles relate to nervous system function, the reader will be prepared to interpret subsequent manscripts in this issue.
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U2 - 10.1080/0264830500381435
DO - 10.1080/0264830500381435
M3 - Review article
C2 - 16401542
AN - SCOPUS:30644470964
SN - 0954-0261
VL - 17
SP - 443
EP - 449
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 6
ER -