Antibody was eluted from the kidney of a patient who died of renal failure with nephritis secondary to subacute bacterial endocarditis (SBE). The eluate was shown to specifically recombine with the bacteria cultured from the patient's blood antemortem. Antiglomerular basement membrane antibody was also present, but rheumatoid factor activity could not be demonstrated in the eluate. These findings support the concept of antigen-antibody complex mediated renal damage in the pathogenesis of SBE nephritis.
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