TY - JOUR
T1 - The identification of OCD-related subgroups based on comorbidity
AU - Nestadt, Gerald
AU - Addington, Anjene
AU - Samuels, Jack
AU - Liang, Kung-Yee
AU - Bienvenu, O. Joseph
AU - Riddle, Mark
AU - Grados, Marco
AU - Hoehn-Saric, Rudolf
AU - Cullen, Bernadette
N1 - Funding Information:
Research supported by National Institutes of Health (NIH) Grant no. R01 MH50214 and by NIH, National Center for Research Resources (NCRR), and the Adult Outpatient Unit of the General Clinical Research Center (OPD-GCRC) Grant no. RR00052.
PY - 2003/5/15
Y1 - 2003/5/15
N2 - Background: Individuals with obsessive-compulsive disorder (OCD) frequently have other psychiatric disorders. This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups. Methods: The study included 450 subjects, case and control probands and their first-degree relatives, and LCA was used to derive empirically based subgroups of 10 disorders: OCD, obsessive-compulsive personality disorder (OCPD), recurrent major depressive disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG), tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and eating disorders (EDs). The derived classes were compared on several clinical variables. Results: The best fitting model is a four-class structure: minimal disorder, predominant RMDD and GAD, "highly comorbid," and PD/AG and TD. The nature and number of disorders represented suggests that the first classes are distributed ordinally on a dimension of severity, and the fourth class is qualitatively distinct. Support for this structure is based on the number of disorders, age at onset of OCD, neuroticism, and extraversion. Conclusions: In this OCD enriched sample, LCA identified four classes of disorder. These classes appear to conform to two subgroups that may prove useful in investigating the etiology of OCD.
AB - Background: Individuals with obsessive-compulsive disorder (OCD) frequently have other psychiatric disorders. This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups. Methods: The study included 450 subjects, case and control probands and their first-degree relatives, and LCA was used to derive empirically based subgroups of 10 disorders: OCD, obsessive-compulsive personality disorder (OCPD), recurrent major depressive disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG), tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and eating disorders (EDs). The derived classes were compared on several clinical variables. Results: The best fitting model is a four-class structure: minimal disorder, predominant RMDD and GAD, "highly comorbid," and PD/AG and TD. The nature and number of disorders represented suggests that the first classes are distributed ordinally on a dimension of severity, and the fourth class is qualitatively distinct. Support for this structure is based on the number of disorders, age at onset of OCD, neuroticism, and extraversion. Conclusions: In this OCD enriched sample, LCA identified four classes of disorder. These classes appear to conform to two subgroups that may prove useful in investigating the etiology of OCD.
KW - Anxiety disorders
KW - Familiality
KW - Latent class analysis
KW - OCD
KW - OCD spectrum disorders
KW - Subtypes
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U2 - 10.1016/S0006-3223(02)01677-3
DO - 10.1016/S0006-3223(02)01677-3
M3 - Article
C2 - 12742679
AN - SCOPUS:0037721605
VL - 53
SP - 914
EP - 920
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 10
ER -