Abstract
Background: Individuals with obsessive-compulsive disorder (OCD) frequently have other psychiatric disorders. This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups. Methods: The study included 450 subjects, case and control probands and their first-degree relatives, and LCA was used to derive empirically based subgroups of 10 disorders: OCD, obsessive-compulsive personality disorder (OCPD), recurrent major depressive disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG), tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and eating disorders (EDs). The derived classes were compared on several clinical variables. Results: The best fitting model is a four-class structure: minimal disorder, predominant RMDD and GAD, "highly comorbid," and PD/AG and TD. The nature and number of disorders represented suggests that the first classes are distributed ordinally on a dimension of severity, and the fourth class is qualitatively distinct. Support for this structure is based on the number of disorders, age at onset of OCD, neuroticism, and extraversion. Conclusions: In this OCD enriched sample, LCA identified four classes of disorder. These classes appear to conform to two subgroups that may prove useful in investigating the etiology of OCD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 914-920 |
| Number of pages | 7 |
| Journal | Biological Psychiatry |
| Volume | 53 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 15 2003 |
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Keywords
- Anxiety disorders
- Familiality
- Latent class analysis
- OCD
- OCD spectrum disorders
- Subtypes
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
The identification of OCD-related subgroups based on comorbidity. / Nestadt, Gerald; Addington, Anjene; Samuels, Jack; Liang, Kung Yee; Bienvenu, Oscar J; Riddle, Mark A; Grados, Marco; Hoehn-Saric, Rudolf; Cullen, Bernadette.
In: Biological Psychiatry, Vol. 53, No. 10, 15.05.2003, p. 914-920.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The identification of OCD-related subgroups based on comorbidity
AU - Nestadt, Gerald
AU - Addington, Anjene
AU - Samuels, Jack
AU - Liang, Kung Yee
AU - Bienvenu, Oscar J
AU - Riddle, Mark A
AU - Grados, Marco
AU - Hoehn-Saric, Rudolf
AU - Cullen, Bernadette
PY - 2003/5/15
Y1 - 2003/5/15
N2 - Background: Individuals with obsessive-compulsive disorder (OCD) frequently have other psychiatric disorders. This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups. Methods: The study included 450 subjects, case and control probands and their first-degree relatives, and LCA was used to derive empirically based subgroups of 10 disorders: OCD, obsessive-compulsive personality disorder (OCPD), recurrent major depressive disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG), tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and eating disorders (EDs). The derived classes were compared on several clinical variables. Results: The best fitting model is a four-class structure: minimal disorder, predominant RMDD and GAD, "highly comorbid," and PD/AG and TD. The nature and number of disorders represented suggests that the first classes are distributed ordinally on a dimension of severity, and the fourth class is qualitatively distinct. Support for this structure is based on the number of disorders, age at onset of OCD, neuroticism, and extraversion. Conclusions: In this OCD enriched sample, LCA identified four classes of disorder. These classes appear to conform to two subgroups that may prove useful in investigating the etiology of OCD.
AB - Background: Individuals with obsessive-compulsive disorder (OCD) frequently have other psychiatric disorders. This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups. Methods: The study included 450 subjects, case and control probands and their first-degree relatives, and LCA was used to derive empirically based subgroups of 10 disorders: OCD, obsessive-compulsive personality disorder (OCPD), recurrent major depressive disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG), tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and eating disorders (EDs). The derived classes were compared on several clinical variables. Results: The best fitting model is a four-class structure: minimal disorder, predominant RMDD and GAD, "highly comorbid," and PD/AG and TD. The nature and number of disorders represented suggests that the first classes are distributed ordinally on a dimension of severity, and the fourth class is qualitatively distinct. Support for this structure is based on the number of disorders, age at onset of OCD, neuroticism, and extraversion. Conclusions: In this OCD enriched sample, LCA identified four classes of disorder. These classes appear to conform to two subgroups that may prove useful in investigating the etiology of OCD.
KW - Anxiety disorders
KW - Familiality
KW - Latent class analysis
KW - OCD
KW - OCD spectrum disorders
KW - Subtypes
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UR - http://www.scopus.com/inward/citedby.url?scp=0037721605&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(02)01677-3
DO - 10.1016/S0006-3223(02)01677-3
M3 - Article
C2 - 12742679
AN - SCOPUS:0037721605
VL - 53
SP - 914
EP - 920
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 10
ER -