The identification of a SIRT6 activator from brown algae fucus distichus

Minna K. Rahnasto-Rilla, Padraig McLoughlin, Tomasz Kulikowicz, Maire E. Doyle, Vilhelm A. Bohr, Maija Lahtela-Kakkonen, Luigi Ferrucci, Maria Hayes, Ruin Moaddel

Research output: Contribution to journalArticle

Abstract

Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.

Original languageEnglish (US)
Article number190
JournalMarine Drugs
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Fucus
Phaeophyta
Seaweed
Polyphenols
Antihypertensive Agents
Polysaccharides
Mass Spectrometry
Anti-Inflammatory Agents
Neoplasms

Keywords

  • Brown seaweed
  • Fucoidan
  • Sirtuin activators

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Rahnasto-Rilla, M. K., McLoughlin, P., Kulikowicz, T., Doyle, M. E., Bohr, V. A., Lahtela-Kakkonen, M., ... Moaddel, R. (2017). The identification of a SIRT6 activator from brown algae fucus distichus. Marine Drugs, 15(6), [190]. https://doi.org/10.3390/md15060190

The identification of a SIRT6 activator from brown algae fucus distichus. / Rahnasto-Rilla, Minna K.; McLoughlin, Padraig; Kulikowicz, Tomasz; Doyle, Maire E.; Bohr, Vilhelm A.; Lahtela-Kakkonen, Maija; Ferrucci, Luigi; Hayes, Maria; Moaddel, Ruin.

In: Marine Drugs, Vol. 15, No. 6, 190, 01.06.2017.

Research output: Contribution to journalArticle

Rahnasto-Rilla, MK, McLoughlin, P, Kulikowicz, T, Doyle, ME, Bohr, VA, Lahtela-Kakkonen, M, Ferrucci, L, Hayes, M & Moaddel, R 2017, 'The identification of a SIRT6 activator from brown algae fucus distichus', Marine Drugs, vol. 15, no. 6, 190. https://doi.org/10.3390/md15060190
Rahnasto-Rilla MK, McLoughlin P, Kulikowicz T, Doyle ME, Bohr VA, Lahtela-Kakkonen M et al. The identification of a SIRT6 activator from brown algae fucus distichus. Marine Drugs. 2017 Jun 1;15(6). 190. https://doi.org/10.3390/md15060190
Rahnasto-Rilla, Minna K. ; McLoughlin, Padraig ; Kulikowicz, Tomasz ; Doyle, Maire E. ; Bohr, Vilhelm A. ; Lahtela-Kakkonen, Maija ; Ferrucci, Luigi ; Hayes, Maria ; Moaddel, Ruin. / The identification of a SIRT6 activator from brown algae fucus distichus. In: Marine Drugs. 2017 ; Vol. 15, No. 6.
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