The identification of a SIRT6 activator from brown algae fucus distichus

Minna K. Rahnasto-Rilla, Padraig McLoughlin, Tomasz Kulikowicz, Maire Doyle, Vilhelm A. Bohr, Maija Lahtela-Kakkonen, Luigi Ferrucci, Maria Hayes, Ruin Moaddel

Research output: Contribution to journalArticle

Abstract

Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.

Original languageEnglish (US)
Article number190
JournalMarine Drugs
Volume15
Issue number6
DOIs
StatePublished - Jun 2017

Keywords

  • Brown seaweed
  • Fucoidan
  • Sirtuin activators

ASJC Scopus subject areas

  • Drug Discovery

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    Rahnasto-Rilla, M. K., McLoughlin, P., Kulikowicz, T., Doyle, M., Bohr, V. A., Lahtela-Kakkonen, M., Ferrucci, L., Hayes, M., & Moaddel, R. (2017). The identification of a SIRT6 activator from brown algae fucus distichus. Marine Drugs, 15(6), [190]. https://doi.org/10.3390/md15060190