The identification and measurement of two new metabolites of naltrexone in human urine

E. J. Cone, C. W. Gorodetzky, W. D. Darwin, F. I. Carroll, G. A. Brine, C. D. Welch

Research output: Contribution to journalArticlepeer-review

Abstract

Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.

Original languageEnglish (US)
Pages (from-to)413-433
Number of pages21
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume20
Issue number3
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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