The human transcriptome: An unfinished story

Research output: Contribution to journalReview article

Abstract

Despite recent technological advances, the study of the human transcriptome is still in its early stages. Here we provide an overview of the complex human transcriptomic landscape, present the bioinformatics challenges posed by the vast quantities of transcriptomic data, and discuss some of the studies that have tried to determine how much of the human genome is transcribed. Recent evidence has suggested that more than 90% of the human genome is transcribed into RNA. However, this view has been strongly contested by groups of scientists who argued that many of the observed transcripts are simply the result of transcriptional noise. In this review, we conclude that the full extent of transcription remains an open question that will not be fully addressed until we decipher the complete range and biological diversity of the transcribed genomic sequences.

Original languageEnglish (US)
Pages (from-to)344-360
Number of pages17
JournalGenes
Volume3
Issue number3
DOIs
StatePublished - Sep 1 2012

Keywords

  • Pervasive transcription
  • RNA-seq
  • Transcriptome
  • mRNA
  • ncRNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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