The Human Toxome Project

Mounir Bouhifd, Melvin E. Andersen, Christina Baghdikian, Kim Boekelheide, Kevin M. Crofton, Albert J. Fornace, Andre Kleensang, Henghong Li, Carolina Livi, Alexandra Maertens, Patrick D. McMullen, Michael Rosenberg, Russell Thomas, Marguerite Vantangoli, James D. Yager, Liang Zhao, Thomas Hartung

Research output: Contribution to journalArticlepeer-review

Abstract

The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies. regulatory toxicology, safety sciences, transcriptomics, metabolomics, alternative methods.

Original languageEnglish (US)
Pages (from-to)112-124
Number of pages13
JournalALTEX
Volume32
Issue number2
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Pharmacology
  • Medical Laboratory Technology

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