The human serum amyloid A (SAA)-encoding gene GSAA1: nucleotide sequence and possible autocrine-collagenase-inducer function

George H. Sack, C. Conover Talbot

Research output: Contribution to journalArticle

Abstract

We have determined the genomic sequence of the human GSAA1 gene, a member of the family of acute-phase human serum amyloid A (SAA)-encoding genes. This sequence predicts a mature protein of 104 amino acids (aa), several of which differ from residues usually conserved in the sequence of SAA proteins isolated from serum. Despite coding differences, however, the four-exon structure of GSAA1 resembles that of other SAA genes in humans and mice. The N-terminal 25 aa of the mature GSAA1 protein are virtually identical to those of an 'SAA-like' autocrine collagenase inducer produced by rabbit synovial fibroblasts; the latter also differ from the corresponding aa found in SAA in serum. We propose that GSAA1 is the human gene coding for a protein closely related to the SAA, but which is adapted to this important autocrine cytokine function.

Original languageEnglish (US)
Pages (from-to)509-515
Number of pages7
JournalGene
Volume84
Issue number2
DOIs
StatePublished - Dec 14 1989

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Keywords

  • Recombinant DNA
  • acute phase stimuli
  • cytokine
  • exon
  • inflammation
  • intron
  • rabbit

ASJC Scopus subject areas

  • Genetics

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