The human microbiome and its link in prostate cancer risk and pathogenesis

Paul Katongole, Obondo J. Sande, Moses Joloba, Steven J. Reynolds, Nixon Niyonzima

Research output: Contribution to journalReview articlepeer-review

Abstract

There is growing evidence of the microbiome's role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15-20% of all cancers. Furthermore, the interaction of the microbiota, especially the gut microbiota in influencing response to chemotherapy, immunotherapy, and radiotherapy remains an area of active research. Certain microbial species have been linked to the improved clinical outcome when on different cancer therapies. The recent discovery of the urinary microbiome has enabled the study to understand its connection to genitourinary malignancies, especially prostate cancer. Prostate cancer is the second most common cancer in males worldwide. Therefore research into understanding the factors and mechanisms associated with prostate cancer etiology, pathogenesis, and disease progression is of utmost importance. In this review, we explore the current literature concerning the link between the gut and urinary microbiome and prostate cancer risk and pathogenesis.

Original languageEnglish (US)
Article number53
JournalInfectious Agents and Cancer
Volume15
Issue number1
DOIs
StatePublished - Aug 31 2020

Keywords

  • And urinary microbiome
  • Gut microbiome
  • Microbiome
  • Microbiota
  • Prostate cancer

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Infectious Diseases
  • Cancer Research

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