Abstract
Chromogranin A/secretory protein I (CgA) is a glycoprotein that is stored and released along with peptide hormones and neurotransmitters from several tissues, although its exact function is not known. A cDNA (gene symbol CHGA) clone was used as a probe in Southern blot analyses of human-rodent somatic cell hybrid DNAs. Discordancy analysis allowed confirmation of the assignment of the gene to chromosome 14. These results were extended using in situ chromosome hybridization, and a signal was found at 14q32. BglII digestion of genomic DNA from 28 unrelated Caucasian individuals probed with CHGA detected a two-allele RFLP with allelic frequencies of .34 and .66.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 814-818 |
| Number of pages | 5 |
| Journal | American Journal of Human Genetics |
| Volume | 45 |
| Issue number | 5 |
| State | Published - 1989 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics