The human chromogranin A gene: Chromosome assignment and RFLP analysis

W. S. Modi, M. A. Levine, H. N. Seuanez, M. Dean, S. J. O'Brien

Research output: Contribution to journalArticlepeer-review

Abstract

Chromogranin A/secretory protein I (CgA) is a glycoprotein that is stored and released along with peptide hormones and neurotransmitters from several tissues, although its exact function is not known. A cDNA (gene symbol CHGA) clone was used as a probe in Southern blot analyses of human-rodent somatic cell hybrid DNAs. Discordancy analysis allowed confirmation of the assignment of the gene to chromosome 14. These results were extended using in situ chromosome hybridization, and a signal was found at 14q32. BglII digestion of genomic DNA from 28 unrelated Caucasian individuals probed with CHGA detected a two-allele RFLP with allelic frequencies of .34 and .66.

Original languageEnglish (US)
Pages (from-to)814-818
Number of pages5
JournalAmerican Journal of Human Genetics
Volume45
Issue number5
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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