TY - JOUR
T1 - The Hox genes and their roles in oncogenesis
AU - Shah, Nilay
AU - Sukumar, Saraswati
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/5
Y1 - 2010/5
N2 - Hox genes, a highly conserved subgroup of the homeobox superfamily, have crucial roles in development, regulating numerous processes including apoptosis, receptor signalling, differentiation, motility and angiogenesis. Aberrations in Hox gene expression have been reported in abnormal development and malignancy, indicating that altered expression of Hox genes could be important for both oncogenesis and tumour suppression, depending on context. Therefore, Hox gene expression could be important in diagnosis and therapy.
AB - Hox genes, a highly conserved subgroup of the homeobox superfamily, have crucial roles in development, regulating numerous processes including apoptosis, receptor signalling, differentiation, motility and angiogenesis. Aberrations in Hox gene expression have been reported in abnormal development and malignancy, indicating that altered expression of Hox genes could be important for both oncogenesis and tumour suppression, depending on context. Therefore, Hox gene expression could be important in diagnosis and therapy.
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U2 - 10.1038/nrc2826
DO - 10.1038/nrc2826
M3 - Review article
C2 - 20357775
AN - SCOPUS:77951605788
SN - 1474-175X
VL - 10
SP - 361
EP - 371
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 5
ER -