The Hox genes and their roles in oncogenesis

Nilay Shah, Saraswati Sukumar

Research output: Contribution to journalReview articlepeer-review

Abstract

Hox genes, a highly conserved subgroup of the homeobox superfamily, have crucial roles in development, regulating numerous processes including apoptosis, receptor signalling, differentiation, motility and angiogenesis. Aberrations in Hox gene expression have been reported in abnormal development and malignancy, indicating that altered expression of Hox genes could be important for both oncogenesis and tumour suppression, depending on context. Therefore, Hox gene expression could be important in diagnosis and therapy.

Original languageEnglish (US)
Pages (from-to)361-371
Number of pages11
JournalNature Reviews Cancer
Volume10
Issue number5
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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